BDBM6655 3-(9-oxo-9H-fluoren-4-yl)-1-pyridin-2-ylurea::Diarylurea deriv. 15::N-(9-Oxo-9H-fluoren-4-yl)-N -pyridin-2-ylurea

SMILES: O=C(Nc1ccccn1)Nc1cccc2C(=O)c3ccccc3-c12

InChI Key: InChIKey=XVVDNGPUSVDRAJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D2 (Homo sapiens (Human))	BDBM6655 (3-(9-oxo-9H-fluoren-4-yl)-1-pyridin-2-ylurea | Dia...) Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)c3ccccc3-c12 Show InChI InChI=1S/C19H13N3O2/c23-18-13-7-2-1-6-12(13)17-14(18)8-5-9-15(17)21-19(24)22-16-10-3-4-11-20-16/h1-11H,(H2,20,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Swiss Federal Institute of Technology (ETH) Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK4/Cyclin D2 expressed in baculovirus infected insect Sf9 cells using G1 peptide as substrate after 45 mins by Top ...				J Med Chem 59: 4077-86 (2016) BindingDB Entry DOI: 10.7270/Q2FN184P
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human))	BDBM6655 (3-(9-oxo-9H-fluoren-4-yl)-1-pyridin-2-ylurea | Dia...) Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)c3ccccc3-c12 Show InChI InChI=1S/C19H13N3O2/c23-18-13-7-2-1-6-12(13)17-14(18)8-5-9-15(17)21-19(24)22-16-10-3-4-11-20-16/h1-11H,(H2,20,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	30
Banyu Tsukuba Research Institute					Assay Description In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...				J Med Chem 44: 4615-27 (2001) Article DOI: 10.1021/jm0103256 BindingDB Entry DOI: 10.7270/Q2736P3Q
					More data for this Ligand-Target Pair