BDBM6882 3-Acyl-2,6-diaminopyridine deriv. 2b::4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzonitrile

SMILES: Nc1nc(Nc2ccc(cc2)C#N)ccc1C(=O)c1c(F)cccc1F

InChI Key: InChIKey=PEUSGTAOOLZICU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6882   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM6882 (3-Acyl-2,6-diaminopyridine deriv. 2b | 4-({6-amino...) Show SMILES Nc1nc(Nc2ccc(cc2)C#N)ccc1C(=O)c1c(F)cccc1F Show InChI InChI=1S/C19H12F2N4O/c20-14-2-1-3-15(21)17(14)18(26)13-8-9-16(25-19(13)23)24-12-6-4-11(10-22)5-7-12/h1-9H,(H3,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	8.0	30
Johnson & Johnson Pharmaceutical					Assay Description The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...				Bioorg Med Chem Lett 15: 2221-4 (2005) Article DOI: 10.1016/j.bmcl.2005.03.024 BindingDB Entry DOI: 10.7270/Q2XP734K
					More data for this Ligand-Target Pair