BDBM7007 Indenopyrazole deriv. 6::N-[3-(4-methoxyphenyl)-4-oxo-2H,4H-indeno[1,2-c]pyrazol-5-yl]-2-methylpropanamide

SMILES: COc1ccc(cc1)-c1[nH]nc2-c3cccc(NC(=O)C(C)C)c3C(=O)c12

InChI Key: InChIKey=JKYJMEJOTVNJIB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7007   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM7007 (Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...) Show SMILES COc1ccc(cc1)-c1[nH]nc2-c3cccc(NC(=O)C(C)C)c3C(=O)c12 Show InChI InChI=1S/C21H19N3O3/c1-11(2)21(26)22-15-6-4-5-14-16(15)20(25)17-18(23-24-19(14)17)12-7-9-13(27-3)10-8-12/h4-11H,1-3H3,(H,22,26)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Merck Pharmaceutical Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				J Med Chem 44: 1334-6 (2001) Article DOI: 10.1021/jm0100032 BindingDB Entry DOI: 10.7270/Q2DN4387
					More data for this Ligand-Target Pair
CDK2/CycE (Homo sapiens (Human))	BDBM7007 (Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...) Show SMILES COc1ccc(cc1)-c1[nH]nc2-c3cccc(NC(=O)C(C)C)c3C(=O)c12 Show InChI InChI=1S/C21H19N3O3/c1-11(2)21(26)22-15-6-4-5-14-16(15)20(25)17-18(23-24-19(14)17)12-7-9-13(27-3)10-8-12/h4-11H,1-3H3,(H,22,26)(H,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Tours Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin E (unknown origin)				Eur J Med Chem 108: 701-19 (2016) BindingDB Entry DOI: 10.7270/Q22J6DQD
					More data for this Ligand-Target Pair
CDK2/CycE (Homo sapiens (Human))	BDBM7007 (Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...) Show SMILES COc1ccc(cc1)-c1[nH]nc2-c3cccc(NC(=O)C(C)C)c3C(=O)c12 Show InChI InChI=1S/C21H19N3O3/c1-11(2)21(26)22-15-6-4-5-14-16(15)20(25)17-18(23-24-19(14)17)12-7-9-13(27-3)10-8-12/h4-11H,1-3H3,(H,22,26)(H,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Merck Pharmaceutical Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				J Med Chem 44: 1334-6 (2001) Article DOI: 10.1021/jm0100032 BindingDB Entry DOI: 10.7270/Q2DN4387
					More data for this Ligand-Target Pair