BDBM71208 US9546164, 309::US9694002, 309

SMILES: C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1

InChI Key: InChIKey=CIXVIWMKNATLIZ-CRAIPNDOSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 71208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium Channel Complex (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	380	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM71208 (US9546164, 309 | US9694002, 309) Show SMILES C[C@@H](N1CCC[C@H](C1)Oc1cc(F)c(cc1C1CC1)C(=O)NS(C)(=O)=O)c1ccc(Cl)c(n1)C1CC1 |r| Show InChI InChI=1S/C26H31ClFN3O4S/c1-15(23-10-9-21(27)25(29-23)17-7-8-17)31-11-3-4-18(14-31)35-24-13-22(28)20(12-19(24)16-5-6-16)26(32)30-36(2,33)34/h9-10,12-13,15-18H,3-8,11,14H2,1-2H3,(H,30,32)/t15-,18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...				US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4
					More data for this Ligand-Target Pair