BDBM7392 2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one::Indirubin::Indirubin derivative, 1::cid_5318433

SMILES: O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O

InChI Key: InChIKey=CRDNMYFJWFXOCH-YPKPFQOOSA-N

Data: 18 IC50  8 EC50

PDB links: 4 PDB IDs contain this monomer as substructures. 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 7392   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Cancer Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2 (unknown origin)				J Med Chem 62: 4233-4251 (2019) Article DOI: 10.1021/acs.jmedchem.8b01469
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Marthasterias glacialis (starfish))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	7.2	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair
ras protein (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q23N21VG
					More data for this Ligand-Target Pair
Ras-related protein Rab-2A. (Canis lupus familiaris)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2V40SNS
					More data for this Ligand-Target Pair
cell division cycle 42 (GTP binding protein, 25kDa) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q26H4FT9
					More data for this Ligand-Target Pair
cell division cycle 42 (GTP binding protein, 25kDa) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2Z31X2S
					More data for this Ligand-Target Pair
GTP-binding protein (rab7) (Canis lupus familiaris)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2X34VWJ
					More data for this Ligand-Target Pair
ras protein (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2D21W1M
					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1 (Mus musculus)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q24M92ZV
					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1 (Mus musculus)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
NMMLSC Curated by PubChem BioAssay					Assay Description University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2W37TR5
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	8.0	22
Schering AG					Assay Description Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.				Chembiochem 6: 531-40 (2005) Article DOI: 10.1002/cbic.200400108 BindingDB Entry DOI: 10.7270/Q2B56H8H
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 17B (STK17B) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of DRAK2 (unknown origin) using MRLC3 peptide as substrate incubated for 2 hrs by ADP-Glo kinase assay				Bioorg Med Chem Lett 26: 2719-23 (2016) Article DOI: 10.1016/j.bmcl.2016.03.111 BindingDB Entry DOI: 10.7270/Q2N29ZTZ
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of CDK1/Cyclin B (unknown origin) expressed in starfish oocytes using histone h1 as substrate after 10 mins in presence of [gamma32P]ATP b...				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of CDK2/CyclinA (unknown origin)				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of CDK4/Cyclin D1 (unknown origin)				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin)				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
CDK2/CycE (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting method				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
CDK2/CycE (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of CDK2/CyclinE (unknown origin)				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kaiserslautern Curated by ChEMBL					Assay Description Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...				J Med Chem 60: 4949-4962 (2017) Article DOI: 10.1021/acs.jmedchem.7b00324 BindingDB Entry DOI: 10.7270/Q2HM5BMK
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Jamia Hamdard (Hamdard University) Curated by ChEMBL					Assay Description Inhibition of GSK3beta (unknown origin) expressed in sf9 cells using GS-1 as substrate after 30 mins in presence of [gamma32P]ATP				Eur J Med Chem 125: 464-477 (2017) Article DOI: 10.1016/j.ejmech.2016.09.058 BindingDB Entry DOI: 10.7270/Q2CN76CN
					More data for this Ligand-Target Pair
PITSLRE serine/threonine-protein kinase CDC2L1 (Homo sapiens (Human))	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant human CDK expressed in baculovirus infected sf9 cells after 10 mins by SDS-PAGE based autoradiography				J Nat Prod 80: 2178-2187 (2017) Article DOI: 10.1021/acs.jnatprod.7b00390 BindingDB Entry DOI: 10.7270/Q2WW7M9S
					More data for this Ligand-Target Pair
Glycogen Synthase Kinase-3, beta (Porcine)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES O=C1Nc2ccccc2\C1=C1\Nc2ccccc2C1=O Show InChI InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-	PDB GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	30
University of Athens					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				J Med Chem 47: 935-46 (2004) Article DOI: 10.1021/jm031016d BindingDB Entry DOI: 10.7270/Q20G3HB8
					More data for this Ligand-Target Pair