BDBM74784 MLS000527782::SMR000120356::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-7-pyrazolo[1,5-a]pyrimidinyl]-1-piperazinyl]-(2-furanyl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl]-(furan-2-yl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]piperazino]-(2-furyl)methanone::[4-[2-(3,5-dimethoxyphenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl]-(furan-2-yl)methanone::cid_1434708::{4-[2-(3,5-Dimethoxy-phenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]-piperazin-1-yl}-furan-2-yl-methanone

SMILES: COc1cc(OC)cc(c1)-c1cc2nc(C)cc(N3CCN(CC3)C(=O)c3ccco3)n2n1

InChI Key: InChIKey=DHNWRNCXWBONKY-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 74784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b (Homo sapiens (Human))	BDBM74784 (MLS000527782 | SMR000120356 | [4-[2-(3,5-dimethoxy...) Show SMILES COc1cc(OC)cc(c1)-c1cc2nc(C)cc(N3CCN(CC3)C(=O)c3ccco3)n2n1 Show InChI InChI=1S/C24H25N5O4/c1-16-11-23(27-6-8-28(9-7-27)24(30)21-5-4-10-33-21)29-22(25-16)15-20(26-29)17-12-18(31-2)14-19(13-17)32-3/h4-5,10-15H,6-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	3.68E+3	n/a	n/a	n/a	n/a
Broad Institute Curated by PubChem BioAssay					Assay Description Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q280513R
					More data for this Ligand-Target Pair