BDBM76963 US9694011, Example 1 (Compound 17)
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccc(F)cc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
InChI Key: InChIKey=ILYWXMXJQALBEV-GOSISDBHSA-N
Data: 3 Kd
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor(L858R) (Homo sapiens (Human)) | BDBM76963 (US9694011, Example 1 (Compound 17)) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 54 | n/a | n/a | n/a | n/a | 32 |
Jiangsu Medolution Ltd US Patent | Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph... | US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM76963 (US9694011, Example 1 (Compound 17)) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 32 |
Jiangsu Medolution Ltd US Patent | Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph... | US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human)) | BDBM76963 (US9694011, Example 1 (Compound 17)) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 270 | n/a | n/a | n/a | n/a | 32 |
Jiangsu Medolution Ltd US Patent | Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph... | US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4 | |||||||||||
More data for this Ligand-Target Pair |