null

SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)c(Cl)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key: InChIKey=BCVUHZCEHINVMQ-QGZVFWFLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 76973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [L858R] (Homo sapiens (Human))	BDBM76973 (US9694011, Example 2 (Compound 18)) Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)c(Cl)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C |r| Show InChI InChI=1S/C25H23ClN6O2/c1-2-21(33)31-12-6-7-17(14-31)32-25-22(24(27)28-15-29-25)23(30-32)16-10-11-20(19(26)13-16)34-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,27,28,29)/t17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a	32
Jiangsu Medolution Ltd US Patent					Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...				US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM76973 (US9694011, Example 2 (Compound 18)) Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)c(Cl)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C |r| Show InChI InChI=1S/C25H23ClN6O2/c1-2-21(33)31-12-6-7-17(14-31)32-25-22(24(27)28-15-29-25)23(30-32)16-10-11-20(19(26)13-16)34-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,27,28,29)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a	32
Jiangsu Medolution Ltd US Patent					Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...				US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM76973 (US9694011, Example 2 (Compound 18)) Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)c(Cl)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C |r| Show InChI InChI=1S/C25H23ClN6O2/c1-2-21(33)31-12-6-7-17(14-31)32-25-22(24(27)28-15-29-25)23(30-32)16-10-11-20(19(26)13-16)34-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,27,28,29)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a	32
Jiangsu Medolution Ltd US Patent					Assay Description Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...				US Patent US9694011 (2017) BindingDB Entry DOI: 10.7270/Q20K26Q4
					More data for this Ligand-Target Pair