BDBM77003 3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)-piperidine-2,6-dione::US9694015, 6.5::US9694015, Compound B
SMILES: O=C1N(Cc2c1cccc2OCc1ccc(OCCN2CCCC2)cc1)C1CCC(=O)NC1=O
InChI Key: InChIKey=FMKVJIORFDDBBM-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tumor necrosis factor (Homo sapiens (Human)) | BDBM77003 (3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair |