BDBM81392 MPI-0482593

SMILES: CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4ccccn4)cc3c(=O)n2C)CC1

InChI Key: InChIKey=YHSCYTRYAOVEAY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 81392   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM81392 (MPI-0482593) Show SMILES CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4ccccn4)cc3c(=O)n2C)CC1 Show InChI InChI=1S/C32H34ClN7O2/c1-4-13-40(26-10-8-23(9-11-26)31(41)35-20-25-7-5-6-12-34-25)21-24-18-27-29(19-28(24)33)36-30(38(3)32(27)42)22-39-16-14-37(2)15-17-39/h1,5-12,18-19H,13-17,20-22H2,2-3H3,(H,35,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Myriad Pharmaceuticals					Assay Description In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.				Chem Biol 17: 659-64 (2010) Article DOI: 10.1016/j.chembiol.2010.05.008 BindingDB Entry DOI: 10.7270/Q2VT1QJW
					More data for this Ligand-Target Pair