BDBM81631 BZD Scaffold, 1

SMILES: [O-]C(=O)C(N1C(c2ccccc2)C(=O)Nc2ccccc2C1=O)c1ccccc1

InChI Key: InChIKey=ZFSRQYHMEMDRLE-UHFFFAOYSA-M

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 81631   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p53 binding protein (Homo sapiens (Human))	BDBM81631 (BZD Scaffold, 1) Show SMILES [O-]C(=O)C(N1C(c2ccccc2)C(=O)Nc2ccccc2C1=O)c1ccccc1 Show InChI InChI=1S/C23H18N2O4/c26-21-19(15-9-3-1-4-10-15)25(20(23(28)29)16-11-5-2-6-12-16)22(27)17-13-7-8-14-18(17)24-21/h1-14,19-20H,(H,24,26)(H,28,29)/p-1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development					Assay Description Binding assay using 1,4-benzodiazepine-2,5-dione (BZD) scaffold and HDM2-p53 protein.				Chem Biol Drug Des 67: 201-5 (2006) Article DOI: 10.1111/j.1747-0285.2006.00365.x BindingDB Entry DOI: 10.7270/Q2BP018M
					More data for this Ligand-Target Pair