BDBM8224 3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6g

SMILES: Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1

InChI Key: InChIKey=WCAYCTGIGMRVKS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8224   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8224 (3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-...) Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1 |t:7| Show InChI InChI=1S/C16H11ClN2O2/c17-11-7-4-8-12(9-11)18-14-13(15(20)19-16(14)21)10-5-2-1-3-6-10/h1-9H,(H2,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	301	n/a	n/a	n/a	n/a	n/a	n/a
University of Jordan Curated by ChEMBL					Assay Description Inhibition of recombinant GSK3-beta				J Med Chem 51: 2062-77 (2008) Article DOI: 10.1021/jm7009765 BindingDB Entry DOI: 10.7270/Q20Z744C
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM8224 (3-[(3-chlorophenyl)amino]-4-phenyl-2,5-dihydro-1H-...) Show SMILES Clc1cccc(NC2=C(C(=O)NC2=O)c2ccccc2)c1 |t:7| Show InChI InChI=1S/C16H11ClN2O2/c17-11-7-4-8-12(9-11)18-14-13(15(20)19-16(14)21)10-5-2-1-3-6-10/h1-9H,(H2,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	301	n/a	n/a	n/a	n/a	7.0	22
SmithKline Beecham Pharmaceuticals					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 11: 635-9 (2001) Article DOI: 10.1016/s0960-894x(00)00721-6 BindingDB Entry DOI: 10.7270/Q2QV3JRC
					More data for this Ligand-Target Pair