BDBM8288 3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 8c

SMILES: O=C1NC(=O)C(=C1N1CCc2ccccc12)c1ccccc1N(=O)=O

InChI Key: InChIKey=FAYCRVHZDSFSBE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 8288   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM8288 (3-(2,3-dihydro-1H-indol-1-yl)-4-(2-nitrophenyl)-2,...) Show SMILES O=C1NC(=O)C(=C1N1CCc2ccccc12)c1ccccc1N(=O)=O |c:5| Show InChI InChI=1S/C18H13N3O4/c22-17-15(12-6-2-4-8-14(12)21(24)25)16(18(23)19-17)20-10-9-11-5-1-3-7-13(11)20/h1-8H,9-10H2,(H,19,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	7.0	22
SmithKline Beecham Pharmaceuticals					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Chem Biol 7: 793-803 (2000) Article DOI: 10.1016/s1074-5521(00)00025-9 BindingDB Entry DOI: 10.7270/Q2M32T0X
					More data for this Ligand-Target Pair