BDBM8289 3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 8d

SMILES: Clc1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O

InChI Key: InChIKey=STWYGLPNRVNBTD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8289 (3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2...) Show SMILES Clc1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O |c:8| Show InChI InChI=1S/C18H13ClN2O2/c19-13-6-3-5-12(10-13)15-16(18(23)20-17(15)22)21-9-8-11-4-1-2-7-14(11)21/h1-7,10H,8-9H2,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of Jordan Curated by ChEMBL					Assay Description Inhibition of recombinant GSK3-beta				J Med Chem 51: 2062-77 (2008) Article DOI: 10.1021/jm7009765 BindingDB Entry DOI: 10.7270/Q20Z744C
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM8289 (3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2...) Show SMILES Clc1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O |c:8| Show InChI InChI=1S/C18H13ClN2O2/c19-13-6-3-5-12(10-13)15-16(18(23)20-17(15)22)21-9-8-11-4-1-2-7-14(11)21/h1-7,10H,8-9H2,(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	7.0	22
SmithKline Beecham Pharmaceuticals					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Chem Biol 7: 793-803 (2000) Article DOI: 10.1016/s1074-5521(00)00025-9 BindingDB Entry DOI: 10.7270/Q2M32T0X
					More data for this Ligand-Target Pair