BDBM84801 PF-00416121

SMILES: Fc1ccc(cc1)-n1nc(cc(C(=O)NCc2ccccc2C(F)(F)F)c1=O)-c1ccncc1

InChI Key: InChIKey=SZWDNHQJXXWUBD-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 84801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM84801 (PF-00416121) Show SMILES Fc1ccc(cc1)-n1nc(cc(C(=O)NCc2ccccc2C(F)(F)F)c1=O)-c1ccncc1 Show InChI InChI=1S/C24H16F4N4O2/c25-17-5-7-18(8-6-17)32-23(34)19(13-21(31-32)15-9-11-29-12-10-15)22(33)30-14-16-3-1-2-4-20(16)24(26,27)28/h1-13H,14H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc.					Assay Description Binding of inhibitors to unactivated p38a that leads to decreasedphosphorylation of p38alpha by MKK6 was determined by measuringthe activated p38alph...				Chem Biol Drug Des 74: 547-59 (2009) Article DOI: 10.1111/j.1747-0285.2009.00884.x BindingDB Entry DOI: 10.7270/Q2930RPH
					More data for this Ligand-Target Pair				3D Structure (crystal)
MAP kinase p38 (Homo sapiens (Human))	BDBM84801 (PF-00416121) Show SMILES Fc1ccc(cc1)-n1nc(cc(C(=O)NCc2ccccc2C(F)(F)F)c1=O)-c1ccncc1 Show InChI InChI=1S/C24H16F4N4O2/c25-17-5-7-18(8-6-17)32-23(34)19(13-21(31-32)15-9-11-29-12-10-15)22(33)30-14-16-3-1-2-4-20(16)24(26,27)28/h1-13H,14H2,(H,30,33)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Zagreb Curated by ChEMBL					Assay Description Inhibition of MAPK p38 (unknown origin)				Eur J Med Chem 143: 1616-1634 (2018) Article DOI: 10.1016/j.ejmech.2017.10.061 BindingDB Entry DOI: 10.7270/Q2VM4FSS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM84801 (PF-00416121) Show SMILES Fc1ccc(cc1)-n1nc(cc(C(=O)NCc2ccccc2C(F)(F)F)c1=O)-c1ccncc1 Show InChI InChI=1S/C24H16F4N4O2/c25-17-5-7-18(8-6-17)32-23(34)19(13-21(31-32)15-9-11-29-12-10-15)22(33)30-14-16-3-1-2-4-20(16)24(26,27)28/h1-13H,14H2,(H,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	>1.25E+4	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc.					Assay Description Inhibition of active p38a MAP kinase by inhibitors was determinedusing a p38a cascade activity assay. A 30-lL reaction mixture wasprepared containing...				Chem Biol Drug Des 74: 547-59 (2009) Article DOI: 10.1111/j.1747-0285.2009.00884.x BindingDB Entry DOI: 10.7270/Q2930RPH
					More data for this Ligand-Target Pair				3D Structure (crystal)