BDBM8559 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4::N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]hexanamide

SMILES: CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1

InChI Key: InChIKey=ZYZXVKYLMUKBGC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8559   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8559 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...) Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1 Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	437	n/a	n/a	n/a	n/a	7.2	22
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM8559 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...) Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1 Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8559 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 4 | N-[6-(...) Show SMILES CCCCCC(=O)Nc1ncnc2oc(cc12)-c1ccc(OC)cc1 Show InChI InChI=1S/C19H21N3O3/c1-3-4-5-6-17(23)22-18-15-11-16(25-19(15)21-12-20-18)13-7-9-14(24-2)10-8-13/h7-12H,3-6H2,1-2H3,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair