BDBM8568 3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]benzamide::4-Acylamino-6-arylfuro[2,3-d]pyrimidine 13

SMILES: COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1

InChI Key: InChIKey=CZXJNJMEDFWKLF-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8568   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8568 (3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1 Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.50E+4	n/a	n/a	n/a	n/a	7.2	22
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8568 (3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1 Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wuhan Institute of Technology Curated by ChEMBL					Assay Description Inhibition of human protein kinase C eta				Eur J Med Chem 164: 448-470 (2019) Article DOI: 10.1007/s00044-005-0126-y BindingDB Entry DOI: 10.7270/Q2WH2SVB
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2) (Homo sapiens (Human))	BDBM8568 (3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1 Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8568 (3-fluoro-N-[6-(4-methoxyphenyl)furo[2,3-d]pyrimidi...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3cccc(F)c3)ncnc2o1 Show InChI InChI=1S/C20H14FN3O3/c1-26-15-7-5-12(6-8-15)17-10-16-18(22-11-23-20(16)27-17)24-19(25)13-3-2-4-14(21)9-13/h2-11H,1H3,(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair