null

SMILES: COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1

InChI Key: InChIKey=QZNRCVXCWYVMOI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8569 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1 Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.2	22
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8569 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1 Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8569 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 14 | N-[6-...) Show SMILES COc1ccc(cc1)-c1cc2c(NC(=O)c3ccco3)ncnc2o1 Show InChI InChI=1S/C18H13N3O4/c1-23-12-6-4-11(5-7-12)15-9-13-16(19-10-20-18(13)25-15)21-17(22)14-3-2-8-24-14/h2-10H,1H3,(H,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair