BDBM8571 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16::N-[6-(4-chlorophenyl)furo[2,3-d]pyrimidin-4-yl]cyclopropanecarboxamide

SMILES: Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1

InChI Key: InChIKey=NVQMLFXNGDWRJW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8571   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM8571 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...) Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1 Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.2	22
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8571 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...) Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1 Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8571 (4-Acylamino-6-arylfuro[2,3-d]pyrimidine 16 | N-[6-...) Show SMILES Clc1ccc(cc1)-c1cc2c(NC(=O)C3CC3)ncnc2o1 Show InChI InChI=1S/C16H12ClN3O2/c17-11-5-3-9(4-6-11)13-7-12-14(18-8-19-16(12)22-13)20-15(21)10-1-2-10/h3-8,10H,1-2H2,(H,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Laboratories					Assay Description The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...				Bioorg Med Chem Lett 14: 3907-11 (2004) Article DOI: 10.1016/j.bmcl.2004.05.064 BindingDB Entry DOI: 10.7270/Q2XD0ZWC
					More data for this Ligand-Target Pair