BDBM85712 1H-imidazol-4-ylacetic acid::CAS_645-65-8::CHEMBL784::Imidazole-4-acetic acid::NSC_96215

SMILES: OC(=O)Cc1cnc[nH]1

InChI Key: InChIKey=PRJKNHOMHKJCEJ-UHFFFAOYSA-N

Data: 1 KI  9 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 85712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA B rho 1 (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alabama at Birmingham Curated by PDSP Ki Database									Mol Pharmacol 58: 1375-80 (2000) Article DOI: 10.1124/mol.58.6.1375 BindingDB Entry DOI: 10.7270/Q2154FK5
					More data for this Ligand-Target Pair
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.10E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair
GABA receptor alpha-4/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.40E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytes				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair
GABA receptor rho-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Partial agonist activity against human rho-2 subunit GABA-C receptor expressed in Xenopus oocytes				J Med Chem 43: 1427-47 (2000) BindingDB Entry DOI: 10.7270/Q2PZ59HT
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist activity on human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytes				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair
GABA receptor alpha-6/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 expressed in Xenopus oocytes at 1 mM				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique				J Med Chem 50: 4147-61 (2007) Article DOI: 10.1021/jm070447j BindingDB Entry DOI: 10.7270/Q2KK9BGK
					More data for this Ligand-Target Pair
GABA-C receptor (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Partial agonist activity against rho-1 subunit GABA-C receptor expressed in Xenopus oocytes, low intrinsic activity (Im 3%)				J Med Chem 43: 1427-47 (2000) BindingDB Entry DOI: 10.7270/Q2PZ59HT
					More data for this Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	4.20E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective agonist dose for human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytes				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM85712 (1H-imidazol-4-ylacetic acid | CAS_645-65-8 | CHEMB...) Show SMILES OC(=O)Cc1cnc[nH]1 Show InChI InChI=1S/C5H6N2O2/c8-5(9)1-4-2-6-3-7-4/h2-3H,1H2,(H,6,7)(H,8,9)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Antagonistic potency against human Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in Xenopus oocytes at 1 mM				Bioorg Med Chem Lett 11: 1573-7 (2001) BindingDB Entry DOI: 10.7270/Q24J0DDQ
					More data for this Ligand-Target Pair