BDBM86525 AMI-193::CAS_77445::CHEMBL79834::NSC_77445
SMILES: Fc1ccc(OCCCN2CCC3(CC2)N(CNC3=O)c2ccccc2)cc1
InChI Key: InChIKey=FJUKDAZEABGEIH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortical regions using [3H]ketanserin as radioligand | J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for binding affinity against dopamine receptor D2 | J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 22.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Research Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) Article DOI: 10.1007/s00210-004-0951-4 BindingDB Entry DOI: 10.7270/Q2M32TBD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat frontal cortical regions using [3H]-8-OH-DPAT as radioligand | J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Research Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) Article DOI: 10.1007/s00210-004-0951-4 BindingDB Entry DOI: 10.7270/Q2M32TBD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vernalis Research Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) Article DOI: 10.1007/s00210-004-0951-4 BindingDB Entry DOI: 10.7270/Q2M32TBD | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine D1 receptor (Mus musculus (Mouse)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 2.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for binding affinity against dopamine receptor D1 | J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat frontal cortical regions using [3H]-mesulergine as radioligand | J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.316 | n/a | n/a | n/a | n/a | n/a | n/a |
ACADIA Pharmaceuticals A/S Curated by ChEMBL | Assay Description Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptor | Bioorg Med Chem Lett 10: 2435-9 (2001) BindingDB Entry DOI: 10.7270/Q2V69HTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pregnane X receptor (Homo sapiens (Human)) | BDBM86525 (AMI-193 | CAS_77445 | CHEMBL79834 | NSC_77445) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a |
National Institutes of Health Chemical Genomics Center Curated by ChEMBL | Assay Description Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay | Drug Metab Dispos 39: 151-9 (2010) Article DOI: 10.1124/dmd.110.035105 BindingDB Entry DOI: 10.7270/Q2JS9S5P | |||||||||||
More data for this Ligand-Target Pair |