BDBM8805 N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-3-methyl-3-phenylbutanamide::Pyrazolo[3,4-d]pyrimidine 13
SMILES: COc1cc(ccc1NC(=O)CC(C)(C)c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
InChI Key: InChIKey=CUIYKFICQYRIMQ-DIVCQZSQSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM8805 (N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Abbott Bioresearch Center | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | Bioorg Med Chem Lett 12: 1687-90 (2002) Article DOI: 10.1016/s0960-894x(02)00196-8 BindingDB Entry DOI: 10.7270/Q2154F84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM8805 (N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Bioresearch Center | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | Bioorg Med Chem Lett 12: 1687-90 (2002) Article DOI: 10.1016/s0960-894x(02)00196-8 BindingDB Entry DOI: 10.7270/Q2154F84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM8805 (N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Bioresearch Center | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | Bioorg Med Chem Lett 12: 1687-90 (2002) Article DOI: 10.1016/s0960-894x(02)00196-8 BindingDB Entry DOI: 10.7270/Q2154F84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM8805 (N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Bioresearch Center | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | Bioorg Med Chem Lett 12: 1687-90 (2002) Article DOI: 10.1016/s0960-894x(02)00196-8 BindingDB Entry DOI: 10.7270/Q2154F84 | |||||||||||
More data for this Ligand-Target Pair |