BDBM88539 US9695131, 48

SMILES: CCOC(=O)C(C)(C)NC(=O)c1cn(-c2ccc3n(C)c(=O)n(C)c3c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O

InChI Key: InChIKey=YLWYFQHIPBEYHJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 88539   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chymase (Mesocricetus auratus (Golden hamster))	BDBM88539 (US9695131, 48) Show SMILES CCOC(=O)C(C)(C)NC(=O)c1cn(-c2ccc3n(C)c(=O)n(C)c3c2)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O Show InChI InChI=1S/C29H30F3N5O6/c1-7-43-25(40)28(3,4)33-23(38)19-15-36(18-11-12-21-22(13-18)35(6)26(41)34(21)5)27(42)37(24(19)39)14-17-9-8-10-20(16(17)2)29(30,31)32/h8-13,15H,7,14H2,1-6H3,(H,33,38)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...				US Patent US9695131 (2017) BindingDB Entry DOI: 10.7270/Q2ZP448Z
					More data for this Ligand-Target Pair