BDBM8870 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-chlorophenyl)urea::CHEMBL382979::KDR Kinase Inhibitor, 9::N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-chlorophenyl)urea::Thienopyrimidine deriv. 96

SMILES: Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12

InChI Key: InChIKey=WALBWDUVJYSLBL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8870 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 48: 6066-83 (2005) Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8870 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.02	n/a	n/a	n/a	n/a	n/a	n/a
Dalian University Curated by ChEMBL					Assay Description Inhibition of KDR				J Mol Graph Model 26: 236-45 (2007) Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8870 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Jiaotong University Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 17: 2126-33 (2007) Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM8870 (3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1...) Show SMILES Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 Show InChI InChI=1S/C19H14ClN5OS/c20-12-2-1-3-14(8-12)25-19(26)24-13-6-4-11(5-7-13)15-9-27-18-16(15)17(21)22-10-23-18/h1-10H,(H2,21,22,23)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Jiaotong University					Assay Description Inhibition assay using KDR.				Chem Biol Drug Des 69: 204-11 (2007) Article DOI: 10.1111/j.1747-0285.2007.00488.x BindingDB Entry DOI: 10.7270/Q2ZG6QQH
					More data for this Ligand-Target Pair