BDBM8906 6-(pyridin-3-yl)naphthalen-2-ol::6-Pyridin-3-ylnaphthalen-2-ol::Pyridine-substituted naphthalene 3::US9271963, 3

SMILES: Oc1ccc2cc(ccc2c1)-c1cccnc1

InChI Key: InChIKey=MDXMZUQFVFTPDO-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8906   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.67E+3	n/a	n/a	n/a	n/a	7.4	37
Saarland University					Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University					Assay Description The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of aromatase				J Med Chem 51: 2481-91 (2008) Article DOI: 10.1021/jm701314u BindingDB Entry DOI: 10.7270/Q2GX4CF5
					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	715	n/a	n/a	n/a	n/a	n/a	37
UNIVERSITAT DES SAARLANDES US Patent					Assay Description V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...				US Patent US9271963 (2016) BindingDB Entry DOI: 10.7270/Q2445KBN
					More data for this Ligand-Target Pair
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	37
UNIVERSITAT DES SAARLANDES US Patent					Assay Description V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...				US Patent US9271963 (2016) BindingDB Entry DOI: 10.7270/Q2445KBN
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Homo sapiens (Human))	BDBM8906 (6-(pyridin-3-yl)naphthalen-2-ol | 6-Pyridin-3-ylna...) Show SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1 Show InChI InChI=1S/C15H11NO/c17-15-6-5-11-8-12(3-4-13(11)9-15)14-2-1-7-16-10-14/h1-10,17H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University					Assay Description The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...				J Med Chem 48: 6632-42 (2005) Article DOI: 10.1021/jm0503704 BindingDB Entry DOI: 10.7270/Q2H41PNT
					More data for this Ligand-Target Pair