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BDBM9205 (2R,4S)-2-benzyl-5-[(5S)-5-benzyl-3-[(4-methoxyphenyl)methyl]-2-oxoimidazolidin-1-yl]-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide::2-imidazolidinone scaffold 21

SMILES: COc1ccc(CN2C[C@H](Cc3ccccc3)N(C[C@@H](O)C[C@@H](Cc3ccccc3)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34)C2=O)cc1

InChI Key: InChIKey=VRSCWHRYULSOAD-PHPRYWTDSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 9205   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A]


(Human immunodeficiency virus type 1)		BDBM9205
PNG
((2R,4S)-2-benzyl-5-[(5S)-5-benzyl-3-[(4-methoxyphe...)
Show SMILES COc1ccc(CN2C[C@H](Cc3ccccc3)N(C[C@@H](O)C[C@@H](Cc3ccccc3)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34)C2=O)cc1 |r|
Show InChI InChI=1S/C39H43N3O5/c1-47-34-18-16-29(17-19-34)24-41-25-32(21-28-12-6-3-7-13-28)42(39(41)46)26-33(43)22-31(20-27-10-4-2-5-11-27)38(45)40-37-35-15-9-8-14-30(35)23-36(37)44/h2-19,31-33,36-37,43-44H,20-26H2,1H3,(H,40,45)/t31-,32+,33+,36-,37+/m1/s1
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MMDB

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UniChem

Similars
Article
PubMed
 5.60 -11.2n/an/an/an/an/a6.425



GlaxoSmithKline



Assay Description
The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...

Bioorg Med Chem Lett 14: 5685-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.038
BindingDB Entry DOI: 10.7270/Q25Q4T9W
More data for this
Ligand-Target Pair