null
SMILES: Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C
InChI Key: InChIKey=SSDFTYWIYVWCIE-KDURUIRLSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human)) | BDBM97672 (US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM97672 (US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM97672 (US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacyclics LLC US Patent | Assay Description IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition... | US Patent US9278100 (2016) BindingDB Entry DOI: 10.7270/Q20C4TMX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM97672 (US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | 7.4 | n/a |
PHARMACYCLICS, INC. US Patent | Assay Description Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in... | US Patent US9133201 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02KC | |||||||||||
More data for this Ligand-Target Pair |
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