BDBM98540 US8492392, 1-11
SMILES: CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1ccc(C)nc1)-c1ccc(Cl)nc1
InChI Key: InChIKey=RUXQZFYHUZKTJB-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM98540 (US8492392, 1-11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 0.600 | -12.6 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Fluorescence polarization assay: The compounds of the following examples had activity in reference assays by exhibiting the ability to inhibit the hy... | US Patent US8492392 (2013) BindingDB Entry DOI: 10.7270/Q2SN07M8 | |||||||||||
More data for this Ligand-Target Pair |