BDBM98629 US8497376, 10

SMILES: COC(=O)N1[C@]2(C)C[C@@](O)(C[C@@]1(C)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=JIHRICXBJJNRBW-BKHFGAQXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM98629 (US8497376, 10) Show SMILES COC(=O)N1[C@]2(C)C[C@@](O)(C[C@@]1(C)C=C2)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:14,t:35,TLB:2:4:8.7.10:13.14| Show InChI InChI=1S/C30H35N5O4/c1-27(2)10-8-19(9-11-27)22-14-20(6-7-23(22)34-25(36)24-32-16-21(15-31)33-24)30(38)17-28(3)12-13-29(4,18-30)35(28)26(37)39-5/h6-8,12-14,16,38H,9-11,17-18H2,1-5H3,(H,32,33)(H,34,36)/t28-,29+,30+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair