BDBM98636 US8497376, 17

SMILES: CC1(C)O[C@H]2[C@@H](O1)[C@]1(C)C[C@H](C[C@@]2(C)O1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=KQBWZHVBJLXMFF-BQGVPGDKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98636   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM98636 (US8497376, 17) Show SMILES CC1(C)O[C@H]2[C@@H](O1)[C@]1(C)C[C@H](C[C@@]2(C)O1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(n1)C1=CCC(C)(C)CC1 |r,t:36| Show InChI InChI=1S/C30H37N5O4/c1-27(2)11-9-17(10-12-27)22-21(35-26(36)25-32-16-19(15-31)33-25)8-7-20(34-22)18-13-29(5)23-24(30(6,14-18)39-29)38-28(3,4)37-23/h7-9,16,18,23-24H,10-14H2,1-6H3,(H,32,33)(H,35,36)/t18-,23-,24+,29+,30-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair