BDBM98649 US8497376, 28

SMILES: C[C@H]1[C@@H]2OC(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=CHBSQOSRYIWTKH-RUASYHTCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98649   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse))	BDBM98649 (US8497376, 28) Show SMILES C[C@H]1[C@@H]2OC(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:5,t:31| Show InChI InChI=1S/C28H32N4O3/c1-16-23-7-8-24(35-23)17(2)28(16,34)19-5-6-22(32-26(33)25-30-15-20(14-29)31-25)21(13-19)18-9-11-27(3,4)12-10-18/h5-9,13,15-17,23-24,34H,10-12H2,1-4H3,(H,30,31)(H,32,33)/t16-,17+,23+,24?,28-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	n/a
Janssen Pharmaceutica N.V. US Patent					Assay Description An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.				US Patent US8497376 (2013) BindingDB Entry DOI: 10.7270/Q2RN36GW
					More data for this Ligand-Target Pair