BindingDB logo
myBDB logout

null

SMILES: C[C@H]1[C@]2(C)OC(C)(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=RXUMFNVUTUEXDZ-FMYORNQOSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98651   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM98651
PNG
(US8497376, 30)
Show SMILES C[C@H]1[C@]2(C)OC(C)(C=C2)[C@@H](C)[C@]1(O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |r,c:7,t:33|
Show InChI InChI=1S/C30H36N4O3/c1-18-28(5)13-14-29(6,37-28)19(2)30(18,36)21-7-8-24(34-26(35)25-32-17-22(16-31)33-25)23(15-21)20-9-11-27(3,4)12-10-20/h7-9,13-15,17-19,36H,10-12H2,1-6H3,(H,32,33)(H,34,35)/t18-,19+,28+,29?,30-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 99n/an/an/an/a7.5n/a



Janssen Pharmaceutica N.V.

US Patent


Assay Description
An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.

US Patent US8497376 (2013)


BindingDB Entry DOI: 10.7270/Q2RN36GW
More data for this
Ligand-Target Pair