BDBM99355 US8497281, 133::US9120769, 66::US9663470, 66

SMILES: CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21

InChI Key: InChIKey=LEOUBWWDMKISSF-ZYZRXSCRSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99355 (US8497281, 133 | US9120769, 66 | US9663470, 66) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r| Show InChI InChI=1S/C24H26N2O2/c1-24(2)19-14-16(9-11-20(19)25-23(24)28)22(27)26-13-5-8-18-17-7-4-3-6-15(17)10-12-21(18)26/h3-4,6-7,9,11,14,18,21H,5,8,10,12-13H2,1-2H3,(H,25,28)/t18?,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	631	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99355 (US8497281, 133 | US9120769, 66 | US9663470, 66) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r| Show InChI InChI=1S/C24H26N2O2/c1-24(2)19-14-16(9-11-20(19)25-23(24)28)22(27)26-13-5-8-18-17-7-4-3-6-15(17)10-12-21(18)26/h3-4,6-7,9,11,14,18,21H,5,8,10,12-13H2,1-2H3,(H,25,28)/t18?,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh US Patent					Assay Description In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...				US Patent US9663470 (2017) BindingDB Entry DOI: 10.7270/Q2V40X8H
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99355 (US8497281, 133 | US9120769, 66 | US9663470, 66) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C(=O)N1CCCC2[C@@H]1CCc1ccccc21 |r| Show InChI InChI=1S/C24H26N2O2/c1-24(2)19-14-16(9-11-20(19)25-23(24)28)22(27)26-13-5-8-18-17-7-4-3-6-15(17)10-12-21(18)26/h3-4,6-7,9,11,14,18,21H,5,8,10,12-13H2,1-2H3,(H,25,28)/t18?,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	631	n/a	n/a	n/a	n/a	6.0	n/a
Boehringer-Ingelheim International GmbH US Patent					Assay Description n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...				US Patent US9120769 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HK9
					More data for this Ligand-Target Pair