BDBM99614 US8501936, 115

SMILES: CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nn12

InChI Key: InChIKey=CBZXUOJTAGQOFC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99614   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99614 (US8501936, 115) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nn12 Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-11-7-19(8-12-21)22-3-2-4-23-26-24(27-29(22)23)25-20-9-5-18(6-10-20)17-28-13-15-35(32,33)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99614 (US8501936, 115) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nn12 Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-11-7-19(8-12-21)22-3-2-4-23-26-24(27-29(22)23)25-20-9-5-18(6-10-20)17-28-13-15-35(32,33)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26.1	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99614 (US8501936, 115) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cccc2nc(Nc3ccc(CN4CCS(=O)(=O)CC4)cc3)nn12 Show InChI InChI=1S/C24H25N5O4S2/c1-34(30,31)21-11-7-19(8-12-21)22-3-2-4-23-26-24(27-29(22)23)25-20-9-5-18(6-10-20)17-28-13-15-35(32,33)16-14-28/h2-12H,13-17H2,1H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair