BDBM99667 US8501936, 168

SMILES: CN1Cc2ccc(Nc3nc4c(cccn4n3)-c3ccc(cc3)S(C)(=O)=O)cc2C1

InChI Key: InChIKey=XDNCIFYMMJWWTA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99667   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM99667 (US8501936, 168) Show SMILES CN1Cc2ccc(Nc3nc4c(cccn4n3)-c3ccc(cc3)S(C)(=O)=O)cc2C1 Show InChI InChI=1S/C22H21N5O2S/c1-26-13-16-5-8-18(12-17(16)14-26)23-22-24-21-20(4-3-11-27(21)25-22)15-6-9-19(10-7-15)30(2,28)29/h3-12H,13-14H2,1-2H3,(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	816	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM99667 (US8501936, 168) Show SMILES CN1Cc2ccc(Nc3nc4c(cccn4n3)-c3ccc(cc3)S(C)(=O)=O)cc2C1 Show InChI InChI=1S/C22H21N5O2S/c1-26-13-16-5-8-18(12-17(16)14-26)23-22-24-21-20(4-3-11-27(21)25-22)15-6-9-19(10-7-15)30(2,28)29/h3-12H,13-14H2,1-2H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	77.6	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM99667 (US8501936, 168) Show SMILES CN1Cc2ccc(Nc3nc4c(cccn4n3)-c3ccc(cc3)S(C)(=O)=O)cc2C1 Show InChI InChI=1S/C22H21N5O2S/c1-26-13-16-5-8-18(12-17(16)14-26)23-22-24-21-20(4-3-11-27(21)25-22)15-6-9-19(10-7-15)30(2,28)29/h3-12H,13-14H2,1-2H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. US Patent					Assay Description The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...				US Patent US8501936 (2013) BindingDB Entry DOI: 10.7270/Q22Z1455
					More data for this Ligand-Target Pair