Wt: 361.6 BDBM39120Purchase | Wt: 339.3 BDBM48804Purchase | Wt: 433.2 BDBM50424495Purchase | Wt: 454.5 BDBM50044628Purchase |
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bcl-2-related protein A1 (Mus musculus (Mouse)) | BDBM39120 (3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford-Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2K072NW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bcl-2-related protein A1 (Mus musculus (Mouse)) | BDBM39120 (3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanford-Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2X065GM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase HKDC1 [W721R] (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2W094D4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4 gamma 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 5.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay | Assay Description Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2RN3686 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National University of Singapore Curated by ChEMBL | Assay Description Inhibition of human RAD51 | Bioorg Med Chem Lett 29: 2286-2289 (2019) Article DOI: 10.1016/j.bmcl.2019.06.024 BindingDB Entry DOI: 10.7270/Q289198W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM39120 (3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chicago Curated by ChEMBL | Assay Description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay | J Med Chem 56: 254-63 (2013) Article DOI: 10.1021/jm301565b BindingDB Entry DOI: 10.7270/Q2VD70R1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM39120 (3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | n/a | n/a | 2.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human RAD51 using 90-mer ssDNA as substrate measured after 30 mins by D-loop assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00766 BindingDB Entry DOI: 10.7270/Q2GX4G9M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assay | J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay | J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PCMD Curated by PubChem BioAssay | Assay Description Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2QN6558 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 4.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
PCMD Curated by PubChem BioAssay | Assay Description Project Title: A screen for modulators of human Rad51, a key DNA repair protein Application Number: MH084119 Assay Submitter: Dr. Alex Mazin Submitte... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2VD6WW6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM50424495 (CHEMBL2316726) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chicago Curated by ChEMBL | Assay Description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay | J Med Chem 56: 254-63 (2013) Article DOI: 10.1021/jm301565b BindingDB Entry DOI: 10.7270/Q2VD70R1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hexokinase HKDC1 [W721R] (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q23F4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM39120 (3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of RAD1 (unknown origin) binding to ssDNA | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM50044628 (CHEBI:4286 | CHEMBL1162148) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of RAD1 (unknown origin) binding to ssDNA | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM50424495 (CHEMBL2316726) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of RAD1 (unknown origin) binding to ssDNA | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Binding affinity to RAD1 (unknown origin) by surface plasmon resonance method | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Inhibition of RAD1 (unknown origin) binding to ssDNA | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human)) | BDBM48804 (3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Binding affinity to human RAD51 in absence of ATP by SPR method | J Med Chem 55: 3011-20 (2012) Article DOI: 10.1021/jm201173g BindingDB Entry DOI: 10.7270/Q2028SKG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cell cycle checkpoint protein RAD1 (Homo sapiens (Human)) | BDBM50044628 (CHEBI:4286 | CHEMBL1162148) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine Curated by ChEMBL | Assay Description Binding affinity to RAD1 (unknown origin) by surface plasmon resonance method | Bioorg Med Chem Lett 24: 3006-13 (2014) Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 | |||||||||||
More data for this Ligand-Target Pair |