BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 40 hits with Last Name = 'fruzi?ski' and Initial = 'a'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50247053
PNG
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1
Show InChI InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 0.300n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Binding affinity to human histamine H3 receptor

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459836
PNG
(CHEMBL4227989)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C21H35NO/c1-4-21(2,3)19-11-13-20(14-12-19)23-18-10-6-9-17-22-15-7-5-8-16-22/h11-14H,4-10,15-18H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 8.80n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM31046
PNG
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10|
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

DrugBank
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
 10n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459827
PNG
(CHEMBL4225644)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C22H37NO.C2H2O4/c1-5-22(3,4)20-11-13-21(14-12-20)24-17-8-6-7-15-23-16-9-10-19(2)18-23;3-1(4)2(5)6/h11-14,19H,5-10,15-18H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 14n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))		BDBM50247053
PNG
(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1
Show InChI InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 17n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Binding affinity to rat histamine H3 receptor

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459832
PNG
(CHEMBL4226427)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C22H37NO/c1-4-22(2,3)20-12-14-21(15-13-20)24-19-11-7-10-18-23-16-8-5-6-9-17-23/h12-15H,4-11,16-19H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 21n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459831
PNG
(CHEMBL4227269)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCC(C)CC2)cc1
Show InChI InChI=1S/C22H37NO/c1-5-22(3,4)20-9-11-21(12-10-20)24-18-8-6-7-15-23-16-13-19(2)14-17-23/h9-12,19H,5-8,13-18H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 23n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459833
PNG
(CHEMBL4226168)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C23H39NO.C2H2O4/c1-5-23(3,4)21-12-14-22(15-13-21)25-18-9-7-6-8-16-24-17-10-11-20(2)19-24;3-1(4)2(5)6/h12-15,20H,5-11,16-19H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 34n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459826
PNG
(CHEMBL4226155)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C24H41NO.C2H2O4/c1-5-24(3,4)22-13-15-23(16-14-22)26-19-10-8-6-7-9-17-25-18-11-12-21(2)20-25;3-1(4)2(5)6/h13-16,21H,5-12,17-20H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 37n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459838
PNG
(CHEMBL4226957)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C23H39NO/c1-4-23(2,3)21-13-15-22(16-14-21)25-20-12-8-7-11-19-24-17-9-5-6-10-18-24/h13-16H,4-12,17-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 41n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485347
PNG
(CHEMBL2046970)
Show SMILES Cl.COc1ccc(\C=C2/NC(=O)N(CC(O)CN3CCN(CC3)c3ccccc3OC)C2=O)cc1OC
Show InChI InChI=1S/C26H32N4O6.ClH/c1-34-22-7-5-4-6-21(22)29-12-10-28(11-13-29)16-19(31)17-30-25(32)20(27-26(30)33)14-18-8-9-23(35-2)24(15-18)36-3;/h4-9,14-15,19,31H,10-13,16-17H2,1-3H3,(H,27,33);1H/b20-14-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 45n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459825
PNG
(CHEMBL4228780)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C21H35NO.C2H2O4/c1-5-21(3,4)19-10-12-20(13-11-19)23-16-7-6-14-22-15-8-9-18(2)17-22;3-1(4)2(5)6/h10-13,18H,5-9,14-17H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 46n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-Methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cell membranes after 90 mins by liquid sc...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459821
PNG
(CHEMBL4227016)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H37NO/c1-4-22(2,3)20-12-14-21(15-13-20)24-19-11-6-5-8-16-23-17-9-7-10-18-23/h12-15H,4-11,16-19H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 47n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485355
PNG
(CHEMBL2046969)
Show SMILES Cl.COc1ccc(\C=C2/NC(=O)N(CC(O)CN3CCN(CC3)c3ccccc3OC)C2=O)c(OC)c1
Show InChI InChI=1S/C26H32N4O6.ClH/c1-34-20-9-8-18(24(15-20)36-3)14-21-25(32)30(26(33)27-21)17-19(31)16-28-10-12-29(13-11-28)22-6-4-5-7-23(22)35-2;/h4-9,14-15,19,31H,10-13,16-17H2,1-3H3,(H,27,33);1H/b21-14-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 52n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459834
PNG
(CHEMBL4227944)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H39NO/c1-4-23(2,3)21-13-15-22(16-14-21)25-20-12-7-5-6-9-17-24-18-10-8-11-19-24/h13-16H,4-12,17-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 55n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485360
PNG
(CHEMBL2046968)
Show SMILES Cl.CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccc(Cl)cc3)C2=O)CC1
Show InChI InChI=1S/C25H29ClN4O4.ClH/c1-2-34-23-6-4-3-5-22(23)29-13-11-28(12-14-29)16-20(31)17-30-24(32)21(27-25(30)33)15-18-7-9-19(26)10-8-18;/h3-10,15,20,31H,2,11-14,16-17H2,1H3,(H,27,33);1H/b21-15-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 59n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459837
PNG
(CHEMBL4227803)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCN2CCC(C)CC2)cc1
Show InChI InChI=1S/C23H39NO/c1-5-23(3,4)21-10-12-22(13-11-21)25-19-9-7-6-8-16-24-17-14-20(2)15-18-24/h10-13,20H,5-9,14-19H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 61n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459839
PNG
(CHEMBL4228195)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCN2CCC(C)CC2)cc1
Show InChI InChI=1S/C24H41NO/c1-5-24(3,4)22-11-13-23(14-12-22)26-20-10-8-6-7-9-17-25-18-15-21(2)16-19-25/h11-14,21H,5-10,15-20H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 64n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459823
PNG
(CHEMBL4225907)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C21H35NO/c1-4-21(2,3)19-11-13-20(14-12-19)23-18-10-9-17-22-15-7-5-6-8-16-22/h11-14H,4-10,15-18H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 68n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-Methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cell membranes after 90 mins by liquid sc...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485348
PNG
(CHEMBL2046967)
Show SMILES Cl.COc1cccc(\C=C2/NC(=O)N(CC(O)CN3CCN(CC3)c3ccccc3OC)C2=O)c1OC
Show InChI InChI=1S/C26H32N4O6.ClH/c1-34-22-9-5-4-8-21(22)29-13-11-28(12-14-29)16-19(31)17-30-25(32)20(27-26(30)33)15-18-7-6-10-23(35-2)24(18)36-3;/h4-10,15,19,31H,11-14,16-17H2,1-3H3,(H,27,33);1H/b20-15-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 70n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485349
PNG
(CHEMBL2046966)
Show SMILES Cl.CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3cccc(OC)c3OC)C2=O)CC1
Show InChI InChI=1S/C27H34N4O6.ClH/c1-4-37-23-10-6-5-9-22(23)30-14-12-29(13-15-30)17-20(32)18-31-26(33)21(28-27(31)34)16-19-8-7-11-24(35-2)25(19)36-3;/h5-11,16,20,32H,4,12-15,17-18H2,1-3H3,(H,28,34);1H/b21-16-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 72n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485356
PNG
(CHEMBL2046965)
Show SMILES Cl.COc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccc(Cl)cc3)C2=O)CC1
Show InChI InChI=1S/C24H27ClN4O4.ClH/c1-33-22-5-3-2-4-21(22)28-12-10-27(11-13-28)15-19(30)16-29-23(31)20(26-24(29)32)14-17-6-8-18(25)9-7-17;/h2-9,14,19,30H,10-13,15-16H2,1H3,(H,26,32);1H/b20-14-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 86n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485350
PNG
(CHEMBL2046964)
Show SMILES Cl.CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccccc3)C2=O)CC1
Show InChI InChI=1S/C25H30N4O4.ClH/c1-2-33-23-11-7-6-10-22(23)28-14-12-27(13-15-28)17-20(30)18-29-24(31)21(26-25(29)32)16-19-8-4-3-5-9-19;/h3-11,16,20,30H,2,12-15,17-18H2,1H3,(H,26,32);1H/b21-16-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 91n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459830
PNG
(CHEMBL4228257)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C25H43NO.C2H2O4/c1-5-25(3,4)23-14-16-24(17-15-23)27-20-11-9-7-6-8-10-18-26-19-12-13-22(2)21-26;3-1(4)2(5)6/h14-17,22H,5-13,18-21H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 121n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459828
PNG
(CHEMBL4227734)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C24H41NO/c1-4-24(2,3)22-14-16-23(17-15-22)26-21-13-9-5-6-10-18-25-19-11-7-8-12-20-25/h14-17H,4-13,18-21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 128n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459822
PNG
(CHEMBL4226963)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C20H33NO/c1-4-20(2,3)18-10-12-19(13-11-18)22-17-9-8-16-21-14-6-5-7-15-21/h10-13H,4-9,14-17H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
 140n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-Methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cell membranes after 90 mins by liquid sc...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459835
PNG
(CHEMBL4228514)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C25H43NO/c1-4-25(2,3)23-15-17-24(18-16-23)27-22-14-10-6-5-7-11-19-26-20-12-8-9-13-21-26/h15-18H,4-14,19-22H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 183n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485351
PNG
(CHEMBL2046963)
Show SMILES Cl.COc1ccc(\C=C2/NC(=O)N(CC(O)CN3CCN(CC3)c3ccccc3)C2=O)cc1OC
Show InChI InChI=1S/C25H30N4O5.ClH/c1-33-22-9-8-18(15-23(22)34-2)14-21-24(31)29(25(32)26-21)17-20(30)16-27-10-12-28(13-11-27)19-6-4-3-5-7-19;/h3-9,14-15,20,30H,10-13,16-17H2,1-2H3,(H,26,32);1H/b21-14-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 198n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485357
PNG
(CHEMBL2046962)
Show SMILES Cl.CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccc(OC)cc3OC)C2=O)CC1
Show InChI InChI=1S/C27H34N4O6.ClH/c1-4-37-24-8-6-5-7-23(24)30-13-11-29(12-14-30)17-20(32)18-31-26(33)22(28-27(31)34)15-19-9-10-21(35-2)16-25(19)36-3;/h5-10,15-16,20,32H,4,11-14,17-18H2,1-3H3,(H,28,34);1H/b22-15-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 231n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459824
PNG
(CHEMBL4226749)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCN2CCC(C)CC2)cc1
Show InChI InChI=1S/C21H35NO/c1-5-21(3,4)19-8-10-20(11-9-19)23-17-7-6-14-22-15-12-18(2)13-16-22/h8-11,18H,5-7,12-17H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 238n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-Methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cell membranes after 90 mins by liquid sc...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485359
PNG
(CHEMBL2046961)
Show SMILES Cl.COc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccccc3)C2=O)CC1
Show InChI InChI=1S/C24H28N4O4.ClH/c1-32-22-10-6-5-9-21(22)27-13-11-26(12-14-27)16-19(29)17-28-23(30)20(25-24(28)31)15-18-7-3-2-4-8-18;/h2-10,15,19,29H,11-14,16-17H2,1H3,(H,25,31);1H/b20-15-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 286n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459840
PNG
(CHEMBL4227677)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCCN2CCC(C)CC2)cc1
Show InChI InChI=1S/C25H43NO/c1-5-25(3,4)23-12-14-24(15-13-23)27-21-11-9-7-6-8-10-18-26-19-16-22(2)17-20-26/h12-15,22H,5-11,16-21H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 308n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485354
PNG
(CHEMBL2046960)
Show SMILES Cl.COc1cccc(\C=C2/NC(=O)N(CC(O)CN3CCN(CC3)c3ccccc3)C2=O)c1OC
Show InChI InChI=1S/C25H30N4O5.ClH/c1-33-22-10-6-7-18(23(22)34-2)15-21-24(31)29(25(32)26-21)17-20(30)16-27-11-13-28(14-12-27)19-8-4-3-5-9-19;/h3-10,15,20,30H,11-14,16-17H2,1-2H3,(H,26,32);1H/b21-15-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 319n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459829
PNG
(CHEMBL4227408)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C24H41NO/c1-4-24(2,3)22-14-16-23(17-15-22)26-21-13-8-6-5-7-10-18-25-19-11-9-12-20-25/h14-17H,4-13,18-21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 326n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 mins

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485352
PNG
(CHEMBL2046959)
Show SMILES Cl.COc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccc(cc3)N(C)C)C2=O)CC1
Show InChI InChI=1S/C26H33N5O4.ClH/c1-28(2)20-10-8-19(9-11-20)16-22-25(33)31(26(34)27-22)18-21(32)17-29-12-14-30(15-13-29)23-6-4-5-7-24(23)35-3;/h4-11,16,21,32H,12-15,17-18H2,1-3H3,(H,27,34);1H/b22-16-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 835n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485358
PNG
(CHEMBL2046958)
Show SMILES Cl.OC(CN1C(=O)N\C(=C/c2ccc(Cl)cc2)C1=O)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H25ClN4O3.ClH/c24-18-8-6-17(7-9-18)14-21-22(30)28(23(31)25-21)16-20(29)15-26-10-12-27(13-11-26)19-4-2-1-3-5-19;/h1-9,14,20,29H,10-13,15-16H2,(H,25,31);1H/b21-14-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 3.70E+3n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50485353
PNG
(CHEMBL2046971)
Show SMILES Cl.CCOc1ccccc1N1CCN(CC(O)CN2C(=O)N\C(=C/c3ccc(cc3)N(C)C)C2=O)CC1
Show InChI InChI=1S/C27H35N5O4.ClH/c1-4-36-25-8-6-5-7-24(25)31-15-13-30(14-16-31)18-22(33)19-32-26(34)23(28-27(32)35)17-20-9-11-21(12-10-20)29(2)3;/h5-12,17,22,33H,4,13-16,18-19H2,1-3H3,(H,28,35);1H/b23-17-;
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 8.70E+3n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by beta scintillation counting

Bioorg Med Chem 20: 4245-57 (2012)


Article DOI: 10.1016/j.bmc.2012.05.064
BindingDB Entry DOI: 10.7270/Q2862K90
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM8610
PNG
(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Show SMILES [H][C@]1(COc2ccc(cc2)N2CCN(CC2)C(C)=O)CO[C@@](Cn2ccnc2)(O1)c1ccc(Cl)cc1Cl |r|
Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CYP3A4 using Luciferin-BE as substrate in presence of NADPH by P450-Glo luminescence assay

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459827
PNG
(CHEMBL4225644)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCC(C)C2)cc1
Show InChI InChI=1S/C22H37NO.C2H2O4/c1-5-22(3,4)20-11-13-21(14-12-20)24-17-8-6-7-15-23-16-9-10-19(2)18-23;3-1(4)2(5)6/h11-14,19H,5-10,15-18H2,1-4H3;(H,3,4)(H,5,6)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 164n/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated intracellular...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50459836
PNG
(CHEMBL4227989)
Show SMILES OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C21H35NO/c1-4-21(2,3)19-11-13-20(14-12-19)23-18-10-6-9-17-22-15-7-5-8-16-22/h11-14H,4-10,15-18H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 157n/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated intracellular...

Bioorg Med Chem 25: 2701-2712 (2017)


Article DOI: 10.1016/j.bmc.2017.03.031
BindingDB Entry DOI: 10.7270/Q2833VPK
More data for this
Ligand-Target Pair