BindingDB PrimarySearch

Found 43 hits with Last Name = 'lopes' and Initial = 'a'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50590814 (CHEMBL5182359) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50590815 (CHEMBL5199785) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50590813 (CHEMBL5204846) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50590815 (CHEMBL5199785) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50590813 (CHEMBL5204846) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
Protein Mdm4 (Homo sapiens (Human))	BDBM50590814 (CHEMBL5182359) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114637 BindingDB Entry DOI: 10.7270/Q29C72CM
TBA					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human CHK2 kinase expressed in insect Sf21 cells using phospho-CREBtide as substrate at 30 uM				Eur J Med Chem 46: 1245-53 (2011) Article DOI: 10.1016/j.ejmech.2011.01.045 BindingDB Entry DOI: 10.7270/Q27M08ZV
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50396783 (CHEMBL2172710) Show SMILES COc1ccc(\C=N\N(C)C(=O)c2ccc(O)cc2)cc1OC Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM				Eur J Med Chem 46: 1245-53 (2011) Article DOI: 10.1016/j.ejmech.2011.01.045 BindingDB Entry DOI: 10.7270/Q27M08ZV
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50396783 (CHEMBL2172710) Show SMILES COc1ccc(\C=N\N(C)C(=O)c2ccc(O)cc2)cc1OC Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50398447 (Aromasin \| EXEMESTANE) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PDB Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50396784 (CHEMBL2172734) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50396783 (CHEMBL2172710) Show SMILES COc1ccc(\C=N\N(C)C(=O)c2ccc(O)cc2)cc1OC Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50396784 (CHEMBL2172734) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50069753 (CHEMBL3407538) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50396782 (CHEMBL2172731) Show SMILES COc1ccc(\C=N\N(C)C(=O)c2ccccc2)cc1OC Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50396784 (CHEMBL2172734) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50396785 (CHEMBL2172707) Show SMILES Clc1ncnc2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	162	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50396783 (CHEMBL2172710) Show SMILES COc1ccc(\C=N\N(C)C(=O)c2ccc(O)cc2)cc1OC Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	206	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4C				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50396785 (CHEMBL2172707) Show SMILES Clc1ncnc2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aromatase (Homo sapiens (Human))	BDBM50069753 (CHEMBL3407538) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM				Eur J Med Chem 46: 1245-53 (2011) Article DOI: 10.1016/j.ejmech.2011.01.045 BindingDB Entry DOI: 10.7270/Q27M08ZV
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50396784 (CHEMBL2172734) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4C				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50069755 (CHEMBL3407536) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50396785 (CHEMBL2172707) Show SMILES Clc1ncnc2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	622	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	622	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aromatase (Homo sapiens (Human))	BDBM50069752 (CHEMBL3407539) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50069755 (CHEMBL3407536) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14769 (6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...) Show SMILES COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aromatase (Homo sapiens (Human))	BDBM50069754 (CHEMBL3407537) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50398447 (Aromasin \| EXEMESTANE) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	DrugBank PDB Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aromatase (Homo sapiens (Human))	BDBM50069752 (CHEMBL3407539) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Aromatase (Homo sapiens (Human))	BDBM50069754 (CHEMBL3407537) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Coimbra Curated by ChEMBL					Assay Description Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...				Eur J Med Chem 87: 336-45 (2014) Article DOI: 10.1016/j.ejmech.2014.09.074 BindingDB Entry DOI: 10.7270/Q2JH3NWD
University of Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM408979 (US10377729, Compound 2OH-PCB80) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
BSIM Therapeutics, S.A. US Patent					Assay Description In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...				US Patent US10377729 (2019) BindingDB Entry DOI: 10.7270/Q2WM1GSC
BSIM Therapeutics, S.A. US Patent					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM408976 (US10377729, Compound AT09-B00) Show SMILES Cc1c(\C=C\c2occc2Cl)occ1C([O-])=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
BSIM Therapeutics, S.A. US Patent					Assay Description In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...				US Patent US10377729 (2019) BindingDB Entry DOI: 10.7270/Q2WM1GSC
BSIM Therapeutics, S.A. US Patent					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM408980 (Thyroxine \| US10377729, T4) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
BSIM Therapeutics, S.A. US Patent					Assay Description In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...				US Patent US10377729 (2019) BindingDB Entry DOI: 10.7270/Q2WM1GSC
BSIM Therapeutics, S.A. US Patent					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM408977 (US10377729, Compound AT09-B06) Show SMILES Cc1oc(\C=C\c2occc2Cl)cc1C([O-])=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
BSIM Therapeutics, S.A. US Patent					Assay Description In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...				US Patent US10377729 (2019) BindingDB Entry DOI: 10.7270/Q2WM1GSC
BSIM Therapeutics, S.A. US Patent					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
BSIM Therapeutics, S.A. US Patent					Assay Description In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...				US Patent US10377729 (2019) BindingDB Entry DOI: 10.7270/Q2WM1GSC
BSIM Therapeutics, S.A. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4C				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Homo sapiens (Human))	BDBM50396785 (CHEMBL2172707) Show SMILES Clc1ncnc2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4C				J Med Chem 55: 7525-45 (2012) Article DOI: 10.1021/jm300514y BindingDB Entry DOI: 10.7270/Q2CC11TC
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50340790 ((E)-N-(4-nitrobenzylidene)-2-naphthohydrazide \| CH...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate				Eur J Med Chem 46: 1245-53 (2011) Article DOI: 10.1016/j.ejmech.2011.01.045 BindingDB Entry DOI: 10.7270/Q27M08ZV
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair