Compile Data Set for Download or QSAR

Found 118 hits with Last Name = 'schiano-moriello' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20461 ((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...) Show SMILES COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O Show InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ del Piemonte Orientale Curated by ChEMBL					Assay Description Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 m...				Bioorg Med Chem Lett 25: 1009-11 (2015) Article DOI: 10.1016/j.bmcl.2015.01.039 BindingDB Entry DOI: 10.7270/Q2VD717Q
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22999 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-(3-pentylph...) Show SMILES CCCCCc1cccc(CC(=O)NCCc2c[nH]c3ccc(O)cc23)c1 Show InChI InChI=1S/C23H28N2O2/c1-2-3-4-6-17-7-5-8-18(13-17)14-23(27)24-12-11-19-16-25-22-10-9-20(26)15-21(19)22/h5,7-10,13,15-16,25-26H,2-4,6,11-12,14H2,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22987 ((5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethy...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C30H42N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(34)31-23-22-26-25-32-29-21-20-27(33)24-28(26)29/h6-7,9-10,12-13,15-16,20-21,24-25,32-33H,2-5,8,11,14,17-19,22-23H2,1H3,(H,31,34)/b7-6-,10-9-,13-12-,16-15-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23000 (JMC506554 Compound 1m | N-[2-(5-hydroxy-1H-indol-3...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Cc3cccc(c3)-c3ccccc3)c2c1 Show InChI InChI=1S/C24H22N2O2/c27-21-9-10-23-22(15-21)20(16-26-23)11-12-25-24(28)14-17-5-4-8-19(13-17)18-6-2-1-3-7-18/h1-10,13,15-16,26-27H,11-12,14H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allylisothiocyanate-induced Ca2+ response preincubated for 5 min...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22989 ((9Z,12Z,15Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]o...) Show SMILES CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h3-4,6-7,9-10,18-19,22-23,30-31H,2,5,8,11-17,20-21H2,1H3,(H,29,32)/b4-3-,7-6-,10-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23015 (3-phenylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(c3)-c3ccccc3)c2c1 Show InChI InChI=1S/C23H20N2O3/c26-19-9-10-22-21(14-19)18(15-25-22)11-12-24-23(27)28-20-8-4-7-17(13-20)16-5-2-1-3-6-16/h1-10,13-15,25-26H,11-12H2,(H,24,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22998 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-9-phenylnonan...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)CCCCCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C25H32N2O2/c28-22-14-15-24-23(18-22)21(19-27-24)16-17-26-25(29)13-9-4-2-1-3-6-10-20-11-7-5-8-12-20/h5,7-8,11-12,14-15,18-19,27-28H,1-4,6,9-10,13,16-17H2,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23007 (3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-(3-phenylph...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Nc3cccc(c3)-c3ccccc3)c2c1 Show InChI InChI=1S/C23H21N3O2/c27-20-9-10-22-21(14-20)18(15-25-22)11-12-24-23(28)26-19-8-4-7-17(13-19)16-5-2-1-3-6-16/h1-10,13-15,25,27H,11-12H2,(H2,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22995 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]dodecanamide |...) Show SMILES CCCCCCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C22H34N2O2/c1-2-3-4-5-6-7-8-9-10-11-22(26)23-15-14-18-17-24-21-13-12-19(25)16-20(18)21/h12-13,16-17,24-25H,2-11,14-15H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Heat sensitive channel TRPV3 (Rattus norvegicus)	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPV3 expressed in HEK293 cells assessed as inhibition of thymol-induced Ca2+ response preincubated for 5 mins followed by...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22994 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]undecanamide |...) Show SMILES CCCCCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C21H32N2O2/c1-2-3-4-5-6-7-8-9-10-21(25)22-14-13-17-16-23-20-12-11-18(24)15-19(17)20/h11-12,15-16,23-24H,2-10,13-14H2,1H3,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22990 ((6Z,9Z,12Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]oc...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/CCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h6-7,9-10,12-13,18-19,22-23,30-31H,2-5,8,11,14-17,20-21H2,1H3,(H,29,32)/b7-6-,10-9-,13-12-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50103439 (CHEMBL3398239) Show SMILES CCCCCCCC\C=C/CCCCCCCCn1nnc(n1)-c1ccc(O)c(OC)c1 Show InChI InChI=1S/C26H42N4O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-30-28-26(27-29-30)23-19-20-24(31)25(22-23)32-2/h10-11,19-20,22,31H,3-9,12-18,21H2,1-2H3/b11-10-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ del Piemonte Orientale Curated by ChEMBL					Assay Description Antagonist activity against rat recombinant TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced Ca2+ influx pre-treated 5 mins bef...				Bioorg Med Chem Lett 25: 1009-11 (2015) Article DOI: 10.1016/j.bmcl.2015.01.039 BindingDB Entry DOI: 10.7270/Q2VD717Q
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2 (Rattus norvegicus)	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ response preincubated for 5 mins followed by LP...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23026 (4-(benzyloxy)phenyl N-[2-(5-hydroxy-1H-indol-3-yl)...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(OCc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C24H22N2O4/c27-19-6-11-23-22(14-19)18(15-26-23)12-13-25-24(28)30-21-9-7-20(8-10-21)29-16-17-4-2-1-3-5-17/h1-11,14-15,26-27H,12-13,16H2,(H,25,28)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50103440 (CHEMBL3398238) Show SMILES CCCCCCCCCn1nnc(n1)-c1ccc(O)c(OC)c1 Show InChI InChI=1S/C17H26N4O2/c1-3-4-5-6-7-8-9-12-21-19-17(18-20-21)14-10-11-15(22)16(13-14)23-2/h10-11,13,22H,3-9,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ del Piemonte Orientale Curated by ChEMBL					Assay Description Antagonist activity against rat recombinant TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced Ca2+ influx pre-treated 5 mins bef...				Bioorg Med Chem Lett 25: 1009-11 (2015) Article DOI: 10.1016/j.bmcl.2015.01.039 BindingDB Entry DOI: 10.7270/Q2VD717Q
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23022 (3-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]c...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(I)c3)c2c1 Show InChI InChI=1S/C17H15IN2O3/c18-12-2-1-3-14(8-12)23-17(22)19-7-6-11-10-20-16-5-4-13(21)9-15(11)16/h1-5,8-10,20-21H,6-7H2,(H,19,22)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22991 ((9Z,12Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octad...) Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H42N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h6-7,9-10,18-19,22-23,30-31H,2-5,8,11-17,20-21H2,1H3,(H,29,32)/b7-6-,10-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23020 (3-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C17H15ClN2O3/c18-12-2-1-3-14(8-12)23-17(22)19-7-6-11-10-20-16-5-4-13(21)9-15(11)16/h1-5,8-10,20-21H,6-7H2,(H,19,22)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22997 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-8-phenyloctan...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)CCCCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C24H30N2O2/c27-21-13-14-23-22(17-21)20(18-26-23)15-16-25-24(28)12-8-3-1-2-5-9-19-10-6-4-7-11-19/h4,6-7,10-11,13-14,17-18,26-27H,1-3,5,8-9,12,15-16H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23018 (3-(trifluoromethyl)phenyl N-[2-(5-hydroxy-1H-indol...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)12-2-1-3-14(8-12)26-17(25)22-7-6-11-10-23-16-5-4-13(24)9-15(11)16/h1-5,8-10,23-24H,6-7H2,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23014 (3-pentylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES CCCCCc1cccc(OC(=O)NCCc2c[nH]c3ccc(O)cc23)c1 Show InChI InChI=1S/C22H26N2O3/c1-2-3-4-6-16-7-5-8-19(13-16)27-22(26)23-12-11-17-15-24-21-10-9-18(25)14-20(17)21/h5,7-10,13-15,24-25H,2-4,6,11-12H2,1H3,(H,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22992 ((9Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadec-9...) Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H44N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h9-10,18-19,22-23,30-31H,2-8,11-17,20-21H2,1H3,(H,29,32)/b10-9-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23004 (3-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1-(3-pentylph...) Show SMILES CCCCCc1cccc(NC(=O)NCCc2c[nH]c3ccc(O)cc23)c1 Show InChI InChI=1S/C22H27N3O2/c1-2-3-4-6-16-7-5-8-18(13-16)25-22(27)23-12-11-17-15-24-21-10-9-19(26)14-20(17)21/h5,7-10,13-15,24,26H,2-4,6,11-12H2,1H3,(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced Ca2+ response preincubated for 5 mins followed by...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23010 ((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl N-[2-...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCOC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C31H44N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-36-31(35)32-23-22-27-26-33-30-21-20-28(34)25-29(27)30/h6-7,9-10,12-13,15-16,20-21,25-26,33-34H,2-5,8,11,14,17-19,22-24H2,1H3,(H,32,35)/b7-6-,10-9-,13-12-,16-15-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50103441 (CHEMBL3398241) Show SMILES CCCCCC[C@H](C\C=C/CCCCCCCCn1nnc(n1)-c1ccc(O)c(OC)c1)OC(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C34H48N4O4/c1-3-4-5-16-21-30(42-33(40)26-28-19-14-13-15-20-28)22-17-11-9-7-6-8-10-12-18-25-38-36-34(35-37-38)29-23-24-31(39)32(27-29)41-2/h11,13-15,17,19-20,23-24,27,30,39H,3-10,12,16,18,21-22,25-26H2,1-2H3/b17-11-/t30-/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ del Piemonte Orientale Curated by ChEMBL					Assay Description Antagonist activity against rat recombinant TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced Ca2+ influx pre-treated 5 mins bef...				Bioorg Med Chem Lett 25: 1009-11 (2015) Article DOI: 10.1016/j.bmcl.2015.01.039 BindingDB Entry DOI: 10.7270/Q2VD717Q
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23014 (3-pentylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES CCCCCc1cccc(OC(=O)NCCc2c[nH]c3ccc(O)cc23)c1 Show InChI InChI=1S/C22H26N2O3/c1-2-3-4-6-16-7-5-8-19(13-16)27-22(26)23-12-11-17-15-24-21-10-9-18(25)14-20(17)21/h5,7-10,13-15,24-25H,2-4,6,11-12H2,1H3,(H,23,26)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ response preincubated for 5 mins follow...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23016 (3-tert-butylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)e...) Show SMILES CC(C)(C)c1cccc(OC(=O)NCCc2c[nH]c3ccc(O)cc23)c1 Show InChI InChI=1S/C21H24N2O3/c1-21(2,3)15-5-4-6-17(11-15)26-20(25)22-10-9-14-13-23-19-8-7-16(24)12-18(14)19/h4-8,11-13,23-24H,9-10H2,1-3H3,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23003 (1-[(4-tert-butylphenyl)methyl]-3-[2-(5-hydroxy-1H-...) Show SMILES CC(C)(C)c1ccc(CNC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1 Show InChI InChI=1S/C22H27N3O2/c1-22(2,3)17-6-4-15(5-7-17)13-25-21(27)23-11-10-16-14-24-20-9-8-18(26)12-19(16)20/h4-9,12,14,24,26H,10-11,13H2,1-3H3,(H2,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat))	BDBM50548384 (CHEMBL4762439) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1Cc1c(CCCCC)cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c1O |r,t:11,38| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced Ca2+ response preincubated for 5 mins followed by...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Rattus norvegicus)	BDBM50548384 (CHEMBL4762439) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1Cc1c(CCCCC)cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c1O |r,t:11,38| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allylisothiocyanate-induced Ca2+ response preincubated for 5 min...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23023 (4-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]c...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(I)cc3)c2c1 Show InChI InChI=1S/C17H15IN2O3/c18-12-1-4-14(5-2-12)23-17(22)19-8-7-11-10-20-16-6-3-13(21)9-15(11)16/h1-6,9-10,20-21H,7-8H2,(H,19,22)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23017 (4-tert-butylphenyl N-[2-(5-hydroxy-1H-indol-3-yl)e...) Show SMILES CC(C)(C)c1ccc(OC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1 Show InChI InChI=1S/C21H24N2O3/c1-21(2,3)15-4-7-17(8-5-15)26-20(25)22-11-10-14-13-23-19-9-6-16(24)12-18(14)19/h4-9,12-13,23-24H,10-11H2,1-3H3,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus)	BDBM50318484 (2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...) Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11| Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK1016790A-induced Ca2+ response preincubated for 5 mins follow...				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00668 BindingDB Entry DOI: 10.7270/Q2ZW1QJH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23019 (4-(trifluoromethyl)phenyl N-[2-(5-hydroxy-1H-indol...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(cc3)C(F)(F)F)c2c1 Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)12-1-4-14(5-2-12)26-17(25)22-8-7-11-10-23-16-6-3-13(24)9-15(11)16/h1-6,9-10,23-24H,7-8H2,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM23021 (4-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C17H15ClN2O3/c18-12-1-4-14(5-2-12)23-17(22)19-8-7-11-10-20-16-6-3-13(21)9-15(11)16/h1-6,9-10,20-21H,7-8H2,(H,19,22)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM22987 ((5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethy...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C30H42N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(34)31-23-22-26-25-32-29-21-20-27(33)24-28(26)29/h6-7,9-10,12-13,15-16,20-21,24-25,32-33H,2-5,8,11,14,17-19,22-23H2,1H3,(H,31,34)/b7-6-,10-9-,13-12-,16-15-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM22996 (N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-7-phenylhepta...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)CCCCCCc3ccccc3)c2c1 Show InChI InChI=1S/C23H28N2O2/c26-20-12-13-22-21(16-20)19(17-25-22)14-15-24-23(27)11-7-2-1-4-8-18-9-5-3-6-10-18/h3,5-6,9-10,12-13,16-17,25-26H,1-2,4,7-8,11,14-15H2,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM22989 ((9Z,12Z,15Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]o...) Show SMILES CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h3-4,6-7,9-10,18-19,22-23,30-31H,2,5,8,11-17,20-21H2,1H3,(H,29,32)/b4-3-,7-6-,10-9-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM22990 ((6Z,9Z,12Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]oc...) Show SMILES CCCCC\C=C/C\C=C/C\C=C/CCCCC(=O)NCCc1c[nH]c2ccc(O)cc12 Show InChI InChI=1S/C28H40N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(32)29-21-20-24-23-30-27-19-18-25(31)22-26(24)27/h6-7,9-10,12-13,18-19,22-23,30-31H,2-5,8,11,14-17,20-21H2,1H3,(H,29,32)/b7-6-,10-9-,13-12-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	9.0	37
University of Rome La Sapienza					Assay Description The effect of the test compounds on the enzymatic hydrolysis of [14C]anandamide was evaluated by using membranes prepared from rat brain. [14C]Ethano...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23026 (4-(benzyloxy)phenyl N-[2-(5-hydroxy-1H-indol-3-yl)...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(OCc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C24H22N2O4/c27-19-6-11-23-22(14-19)18(15-26-23)12-13-25-24(28)30-21-9-7-20(8-10-21)29-16-17-4-2-1-3-5-17/h1-11,14-15,26-27H,12-13,16H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23025 (4-methoxyphenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethy...) Show SMILES COc1ccc(OC(=O)NCCc2c[nH]c3ccc(O)cc23)cc1 Show InChI InChI=1S/C18H18N2O4/c1-23-14-3-5-15(6-4-14)24-18(22)19-9-8-12-11-20-17-7-2-13(21)10-16(12)17/h2-7,10-11,20-21H,8-9H2,1H3,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23024 (N-arachidonoylserotonin carbamate analogue, 3o | n...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc4ccccc4c3)c2c1 Show InChI InChI=1S/C21H18N2O3/c24-17-6-8-20-19(12-17)16(13-23-20)9-10-22-21(25)26-18-7-5-14-3-1-2-4-15(14)11-18/h1-8,11-13,23-24H,9-10H2,(H,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23023 (4-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]c...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(I)cc3)c2c1 Show InChI InChI=1S/C17H15IN2O3/c18-12-1-4-14(5-2-12)23-17(22)19-8-7-11-10-20-16-6-3-13(21)9-15(11)16/h1-6,9-10,20-21H,7-8H2,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23022 (3-iodophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]c...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(I)c3)c2c1 Show InChI InChI=1S/C17H15IN2O3/c18-12-2-1-3-14(8-12)23-17(22)19-7-6-11-10-20-16-5-4-13(21)9-15(11)16/h1-5,8-10,20-21H,6-7H2,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23021 (4-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C17H15ClN2O3/c18-12-1-4-14(5-2-12)23-17(22)19-8-7-11-10-20-16-6-3-13(21)9-15(11)16/h1-6,9-10,20-21H,7-8H2,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM23020 (3-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl...) Show SMILES Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C17H15ClN2O3/c18-12-2-1-3-14(8-12)23-17(22)19-7-6-11-10-20-16-5-4-13(21)9-15(11)16/h1-5,8-10,20-21H,6-7H2,(H,19,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
University of Rome La Sapienza					Assay Description The antagonistic effects of test compounds were evaluated using HEK293 cells stably overexpressing human TRPV1. Experiments were carried out by measu...				J Med Chem 50: 6554-69 (2007) Article DOI: 10.1021/jm070678q BindingDB Entry DOI: 10.7270/Q2JH3JGS
					More data for this Ligand-Target Pair

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