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Compile Data Set for Download or QSAR

Found 128 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 2'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463972
PNG
(CHEMBL4249976)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)N\N=C\c1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H42N2O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(30)28-27-22-23-19-20-24(29)25(21-23)31-2/h10-11,19-22,29H,3-9,12-18H2,1-2H3,(H,28,30)/b11-10-,27-22+
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n/an/a 120n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM20460
PNG
((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H43NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h10-11,19-21,28H,3-9,12-18,22H2,1-2H3,(H,27,29)/b11-10-
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n/an/a 160n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463948
PNG
(CHEMBL4249973)
Show SMILES CCCCCCCCCCCCCCCC(=O)N\N=C\c1ccc(O)c(OC)c1
Show InChI InChI=1S/C24H40N2O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-24(28)26-25-20-21-17-18-22(27)23(19-21)29-2/h17-20,27H,3-16H2,1-2H3,(H,26,28)/b25-20+
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Mus musculus)		BDBM50531764
PNG
(CHEMBL1451908)
Show SMILES COc1ccc(cc1)-c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O3S/c1-28-14-6-4-13(5-7-14)16-11-17(20(21,22)23)26-19(25-16)30-10-8-18(27)24-12-15-3-2-9-29-15/h2-7,9,11H,8,10,12H2,1H3,(H,24,27)
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n/an/a 460n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPV2 expressed in HEK293T cells assessed as inhibition of 2-APB evoked currents at -60 mV holding potential by whole-ce...

J Med Chem 62: 1373-1384 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01496
BindingDB Entry DOI: 10.7270/Q269771K
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463944
PNG
(CHEMBL1672687)
Show SMILES CCCCCCCC\C=C/CCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C30H51NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-30(33)31-26-27-23-24-28(32)29(25-27)34-2/h10-11,23-25,32H,3-9,12-22,26H2,1-2H3,(H,31,33)/b11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50056471
PNG
((9Z,12Z)-Octadeca-9,12-dienoic acid (2-hydroxy-eth...)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h6-7,9-10,22H,2-5,8,11-19H2,1H3,(H,21,23)/b7-6-,10-9-
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n/an/a 650n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463965
PNG
(CHEMBL1232565)
Show SMILES CCCCCCCC\C=C/CCCCCCCCCCCC(N)=O
Show InChI InChI=1S/C22H43NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h9-10H,2-8,11-21H2,1H3,(H2,23,24)/b10-9-
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n/an/a 670n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463962
PNG
(CHEMBL1672682)
Show SMILES CCCCCCCC\C=C/CCCCCCCCCCCC(=O)NCCO
Show InChI InChI=1S/C24H47NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24(27)25-22-23-26/h9-10,26H,2-8,11-23H2,1H3,(H,25,27)/b10-9-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Homo sapiens)		BDBM50511105
PNG
(GWP-42004 | Gwp42004 | O-4394 | THCV | Tetrahydroc...)
Show SMILES [H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)Oc1cc(CCC)cc(O)c21 |r,t:2|
Show InChI InChI=1S/C19H26O2/c1-5-6-13-10-16(20)18-14-9-12(2)7-8-15(14)19(3,4)21-17(18)11-13/h9-11,14-15,20H,5-8H2,1-4H3/t14-,15-/m1/s1
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TBA



Citation and Details

Article DOI: 10.1021/acs.jnatprod.0c00965
BindingDB Entry DOI: 10.7270/Q2057KWP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463951
PNG
(CHEMBL4243028)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C30H49NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-30(33)31-26-27-23-24-28(32)29(25-27)34-2/h7-8,10-11,23-25,32H,3-6,9,12-22,26H2,1-2H3,(H,31,33)/b8-7-,11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM22988
PNG
((5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO
Show InChI InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
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n/an/a 960n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463946
PNG
(CHEMBL4243663)
Show SMILES [#8]-[#6](=O)C(F)(F)F.[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6@H](-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1 |r|
Show InChI InChI=1S/C29H50N2O3Se.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-35-24-26(30)29(33)31-23-25-19-20-27(32)28(22-25)34-2;3-2(4,5)1(6)7/h10-11,19-20,22,26,32H,3-9,12-18,21,23-24,30H2,1-2H3,(H,31,33);(H,6,7)/b11-10-;/t26-;/m0./s1
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50318484
PNG
(2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...)
Show SMILES CCCCCc1cc(O)c([C@@H]2C=C(C)CC[C@H]2C(C)=C)c(O)c1 |r,t:11|
Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ response preincubated for 5 mins followed by LP...

Citation and Details

Article DOI: 10.1021/acs.jnatprod.0c00668
BindingDB Entry DOI: 10.7270/Q2ZW1QJH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463954
PNG
(CHEMBL4238836)
Show SMILES [#8]-[#6](=O)C(F)(F)F.[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6@H](-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1 |r|
Show InChI InChI=1S/C27H48N2O3Se.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-33-22-24(28)27(31)29-21-23-17-18-25(30)26(20-23)32-2;3-2(4,5)1(6)7/h17-18,20,24,30H,3-16,19,21-22,28H2,1-2H3,(H,29,31);(H,6,7)/t24-;/m0./s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50150483
PNG
((9Z,12Z)-Octadeca-9,12-dienoic acid amide | CHEMBL...)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(N)=O
Show InChI InChI=1S/C18H33NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H2,19,20)/b7-6-,10-9-
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n/an/a 1.20E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50056471
PNG
((9Z,12Z)-Octadeca-9,12-dienoic acid (2-hydroxy-eth...)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h6-7,9-10,22H,2-5,8,11-19H2,1H3,(H,21,23)/b7-6-,10-9-
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n/an/a 1.40E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463947
PNG
(CHEMBL4242482)
Show SMILES OC(=O)C(F)(F)F.CCCCCCCCCCCCCCCCOC(=O)CSC[C@H](N)C(=O)NCc1ccc(O)c(OC)c1 |r|
Show InChI InChI=1S/C29H50N2O5S.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-36-28(33)23-37-22-25(30)29(34)31-21-24-17-18-26(32)27(20-24)35-2;3-2(4,5)1(6)7/h17-18,20,25,32H,3-16,19,21-23,30H2,1-2H3,(H,31,34);(H,6,7)/t25-;/m0./s1
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463970
PNG
(CHEMBL4241078)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCCSCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C29H47NO3S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h7-8,10-11,19-20,24,31H,3-6,9,12-18,21-23,25H2,1-2H3,(H,30,32)/b8-7-,11-10-
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n/an/a 1.40E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463953
PNG
(CHEMBL4247743)
Show SMILES OC(=O)C(F)(F)F.CCCCCCCCCCCCCCCCSC[C@H](N)C(=O)NCc1ccc(O)c(OC)c1 |r|
Show InChI InChI=1S/C27H48N2O3S.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-33-22-24(28)27(31)29-21-23-17-18-25(30)26(20-23)32-2;3-2(4,5)1(6)7/h17-18,20,24,30H,3-16,19,21-22,28H2,1-2H3,(H,29,31);(H,6,7)/t24-;/m0./s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463958
PNG
(CHEMBL4246820)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1
Show InChI InChI=1S/C29H47NO3Se/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h7-8,10-11,19-20,24,31H,3-6,9,12-18,21-23,25H2,1-2H3,(H,30,32)/b8-7-,11-10-
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n/an/a 1.40E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463960
PNG
(CHEMBL4239872)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6@@H](-[#8])-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1 |r|
Show InChI InChI=1S/C29H49NO4Se/c1-3-4-5-13-16-26(31)17-14-11-9-7-6-8-10-12-15-21-35-22-20-29(33)30-24-25-18-19-27(32)28(23-25)34-2/h11,14,18-19,23,26,31-32H,3-10,12-13,15-17,20-22,24H2,1-2H3,(H,30,33)/b14-11-/t26-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463944
PNG
(CHEMBL1672687)
Show SMILES CCCCCCCC\C=C/CCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C30H51NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-30(33)31-26-27-23-24-28(32)29(25-27)34-2/h10-11,23-25,32H,3-9,12-22,26H2,1-2H3,(H,31,33)/b11-10-
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n/an/a 1.50E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50318487
PNG
(CHEMBL497318 | Cannabigerol)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-c1cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c1
Show InChI InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Universita` del Piemonte Orientale

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant TRPV2 receptor expressed in HEK293 cells assessed as stimulation of intracellular calcium level using Fluo4-AM dy...

J Nat Prod 74: 2019-22 (2011)


Article DOI: 10.1021/np200500p
BindingDB Entry DOI: 10.7270/Q2BR8SKG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Homo sapiens)		BDBM50318487
PNG
(CHEMBL497318 | Cannabigerol)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-c1cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c1
Show InChI InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+
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n/an/a 1.50E+3n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jnatprod.0c00965
BindingDB Entry DOI: 10.7270/Q2057KWP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463963
PNG
(CHEBI:85252 | CHEMBL1482206)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)NCCO
Show InChI InChI=1S/C24H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24(27)25-22-23-26/h3-4,6-7,9-10,12-13,15-16,18-19,26H,2,5,8,11,14,17,20-23H2,1H3,(H,25,27)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
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n/an/a 1.63E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463973
PNG
(CHEMBL4247440)
Show SMILES CCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C18H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h7-8,20H,2-6,9-17H2,1H3,(H,19,21)/b8-7-
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n/an/a 1.70E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463946
PNG
(CHEMBL4243663)
Show SMILES [#8]-[#6](=O)C(F)(F)F.[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6@H](-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1 |r|
Show InChI InChI=1S/C29H50N2O3Se.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-35-24-26(30)29(33)31-23-25-19-20-27(32)28(22-25)34-2;3-2(4,5)1(6)7/h10-11,19-20,22,26,32H,3-9,12-18,21,23-24,30H2,1-2H3,(H,31,33);(H,6,7)/b11-10-;/t26-;/m0./s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM20460
PNG
((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H43NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h10-11,19-21,28H,3-9,12-18,22H2,1-2H3,(H,27,29)/b11-10-
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n/an/a 1.70E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463951
PNG
(CHEMBL4243028)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C30H49NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-30(33)31-26-27-23-24-28(32)29(25-27)34-2/h7-8,10-11,23-25,32H,3-6,9,12-22,26H2,1-2H3,(H,31,33)/b8-7-,11-10-
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463959
PNG
(CHEMBL4251158)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1
Show InChI InChI=1S/C29H49NO3Se/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h10-11,19-20,24,31H,3-9,12-18,21-23,25H2,1-2H3,(H,30,32)/b11-10-
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM29080
PNG
(CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
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n/an/a 1.80E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463979
PNG
(CHEMBL4250167)
Show SMILES OC(=O)C(F)(F)F.CCCCCCCC\C=C/CCCCCCCCSC[C@H](N)C(=O)NCc1ccc(O)c(OC)c1 |r|
Show InChI InChI=1S/C29H50N2O3S.C2HF3O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-35-24-26(30)29(33)31-23-25-19-20-27(32)28(22-25)34-2;3-2(4,5)1(6)7/h10-11,19-20,22,26,32H,3-9,12-18,21,23-24,30H2,1-2H3,(H,31,33);(H,6,7)/b11-10-;/t26-;/m0./s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM23028
PNG
((9Z)-octadec-9-enamide | 14C-labeled oleamide | CH...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(N)=O
Show InChI InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-
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n/an/a 2.10E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM23028
PNG
((9Z)-octadec-9-enamide | 14C-labeled oleamide | CH...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(N)=O
Show InChI InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-
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n/an/a 2.10E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463942
PNG
(CHEMBL1672680)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h7-8,10-11,19-21,28H,3-6,9,12-18,22H2,1-2H3,(H,27,29)/b8-7-,11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50150483
PNG
((9Z,12Z)-Octadeca-9,12-dienoic acid amide | CHEMBL...)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(N)=O
Show InChI InChI=1S/C18H33NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H2,19,20)/b7-6-,10-9-
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n/an/a 2.20E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Homo sapiens)		BDBM50285610
PNG
(CBV | CHEMBL4170268)
Show SMILES CCCc1cc(O)c-2c(OC(C)(C)c3ccc(C)cc-23)c1
Show InChI InChI=1S/C19H22O2/c1-5-6-13-10-16(20)18-14-9-12(2)7-8-15(14)19(3,4)21-17(18)11-13/h7-11,20H,5-6H2,1-4H3
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TBA



Citation and Details

Article DOI: 10.1021/acs.jnatprod.0c00965
BindingDB Entry DOI: 10.7270/Q2057KWP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463971
PNG
(CHEMBL4250772)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6@H](-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1)-[#8]-[#6](=O)-[#6]-c1ccccc1 |r|
Show InChI InChI=1S/C37H55NO5Se/c1-3-4-5-16-21-33(43-37(41)29-31-19-14-13-15-20-31)22-17-11-9-7-6-8-10-12-18-26-44-27-25-36(40)38-30-32-23-24-34(39)35(28-32)42-2/h11,13-15,17,19-20,23-24,28,33,39H,3-10,12,16,18,21-22,25-27,29-30H2,1-2H3,(H,38,40)/b17-11-/t33-/m1/s1
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50353094
PNG
(CHEMBL1823117)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-c1cc(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c1
Show InChI InChI=1S/C26H40O2/c1-6-7-8-15-23-18-25(27)24(26(28)19-23)17-16-22(5)14-10-13-21(4)12-9-11-20(2)3/h11,13,16,18-19,27-28H,6-10,12,14-15,17H2,1-5H3/b21-13+,22-16+
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n/an/a 2.30E+3n/an/an/an/an/an/a



Universita` del Piemonte Orientale

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant TRPV2 receptor expressed in HEK293 cells assessed as stimulation of intracellular calcium level using Fluo4-AM dy...

J Nat Prod 74: 2019-22 (2011)


Article DOI: 10.1021/np200500p
BindingDB Entry DOI: 10.7270/Q2BR8SKG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463444
PNG
(CHEMBL4238978)
Show SMILES [H][C@]12Cc3c(O)cc(CCCCC)cc3O[C@]1(C)CC[C@@H](I)C2(C)C |r|
Show InChI InChI=1S/C21H31IO2/c1-5-6-7-8-14-11-16(23)15-13-18-20(2,3)19(22)9-10-21(18,4)24-17(15)12-14/h11-12,18-19,23H,5-10,13H2,1-4H3/t18-,19-,21-/m1/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced increase in intracellular calcium level pretreated f...

Bioorg Med Chem 26: 4532-4536 (2018)


Article DOI: 10.1016/j.bmc.2018.07.044
BindingDB Entry DOI: 10.7270/Q2M32ZFD
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463945
PNG
(CHEBI:71467 | CHEMBL3358297)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO
Show InChI InChI=1S/C22H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h3-4,6-7,9-10,12-13,15-16,24H,2,5,8,11,14,17-21H2,1H3,(H,23,25)/b4-3-,7-6-,10-9-,13-12-,16-15-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463958
PNG
(CHEMBL4246820)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1
Show InChI InChI=1S/C29H47NO3Se/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h7-8,10-11,19-20,24,31H,3-6,9,12-18,21-23,25H2,1-2H3,(H,30,32)/b8-7-,11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463956
PNG
(CHEMBL4240053)
Show SMILES CCCCCCCC\C=C/CCCCCCCCSCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C29H49NO3S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h10-11,19-20,24,31H,3-9,12-18,21-23,25H2,1-2H3,(H,30,32)/b11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463942
PNG
(CHEMBL1672680)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h7-8,10-11,19-21,28H,3-6,9,12-18,22H2,1-2H3,(H,27,29)/b8-7-,11-10-
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n/an/a 2.60E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463970
PNG
(CHEMBL4241078)
Show SMILES CCCCC\C=C/C\C=C/CCCCCCCCSCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C29H47NO3S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h7-8,10-11,19-20,24,31H,3-6,9,12-18,21-23,25H2,1-2H3,(H,30,32)/b8-7-,11-10-
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463972
PNG
(CHEMBL4249976)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)N\N=C\c1ccc(O)c(OC)c1
Show InChI InChI=1S/C26H42N2O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(30)28-27-22-23-19-20-24(29)25(21-23)31-2/h10-11,19-22,29H,3-9,12-18H2,1-2H3,(H,28,30)/b11-10-,27-22+
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n/an/a 3.00E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463969
PNG
(CHEMBL4248188)
Show SMILES CCCCCCCCCCCCCCCCCCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C28H49NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-28(31)29-24-25-21-22-26(30)27(23-25)32-2/h21-23,30H,3-20,24H2,1-2H3,(H,29,31)
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n/an/a 3.10E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463959
PNG
(CHEMBL4251158)
Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]\[#6]=[#6]/[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6][Se;v2][#6]-[#6]-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])c(-[#8]-[#6])c1
Show InChI InChI=1S/C29H49NO3Se/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34-23-21-29(32)30-25-26-19-20-27(31)28(24-26)33-2/h10-11,19-20,24,31H,3-9,12-18,21-23,25H2,1-2H3,(H,30,32)/b11-10-
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n/an/a 3.20E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463973
PNG
(CHEMBL4247440)
Show SMILES CCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C18H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h7-8,20H,2-6,9-17H2,1H3,(H,19,21)/b8-7-
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n/an/a 3.50E+3n/an/an/an/an/an/a



National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 2


(Rattus norvegicus)		BDBM50463952
PNG
(CHEMBL4243946)
Show SMILES CCCCCCCCCCCCCCCCSCCC(=O)NCc1ccc(O)c(OC)c1
Show InChI InChI=1S/C27H47NO3S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-32-21-19-27(30)28-23-24-17-18-25(29)26(22-24)31-2/h17-18,22,29H,3-16,19-21,23H2,1-2H3,(H,28,30)
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National Research Council (CNR)

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll...

J Med Chem 61: 8255-8281 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00734
BindingDB Entry DOI: 10.7270/Q2222XFP
More data for this
Ligand-Target Pair
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