Found 19 hits with Last Name = 'tiwari' and Initial = 'ad' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570891
![PNG](/data/jpeg/tenK5057/BindingDB_50570891.png) (CHEMBL4872206)Show SMILES O[C@@H](CCc1ccc(O)c(O)c1)CC(=O)O[C@@H]1Cc2c(O)cc(O)cc2C[C@@H]1c1ccc(O)c(O)c1 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TET2 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET1
(Homo sapiens) | BDBM50570893
![PNG](/data/jpeg/tenK5057/BindingDB_50570893.png) (CHEMBL4851104) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal Flag-tagged TET1 (1418 to 2136 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET3
(Homo sapiens) | BDBM50570891
![PNG](/data/jpeg/tenK5057/BindingDB_50570891.png) (CHEMBL4872206)Show SMILES O[C@@H](CCc1ccc(O)c(O)c1)CC(=O)O[C@@H]1Cc2c(O)cc(O)cc2C[C@@H]1c1ccc(O)c(O)c1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TET3 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET1
(Homo sapiens) | BDBM50570891
![PNG](/data/jpeg/tenK5057/BindingDB_50570891.png) (CHEMBL4872206)Show SMILES O[C@@H](CCc1ccc(O)c(O)c1)CC(=O)O[C@@H]1Cc2c(O)cc(O)cc2C[C@@H]1c1ccc(O)c(O)c1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TET1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET3
(Homo sapiens) | BDBM50570893
![PNG](/data/jpeg/tenK5057/BindingDB_50570893.png) (CHEMBL4851104) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal Flag-tagged C-terminal His-tagged TET3 (824 to 1795 residues) expressed in Baculovirus infected Sf9 cells ... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570893
![PNG](/data/jpeg/tenK5057/BindingDB_50570893.png) (CHEMBL4851104) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570898
![PNG](/data/jpeg/tenK5057/BindingDB_50570898.png) (CHEMBL4860506) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570897
![PNG](/data/jpeg/tenK5057/BindingDB_50570897.png) (CHEMBL4872110) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM26106
![PNG](/data/jpeg/tenK2/BindingDB_26106.png) (CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)Show InChI InChI=1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Methylcytosine dioxygenase TET1
(Homo sapiens) | BDBM50508775
![PNG](/data/jpeg/tenK5050/BindingDB_50508775.png) (CHEMBL4457636)Show InChI InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TET1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570894
![PNG](/data/jpeg/tenK5057/BindingDB_50570894.png) (CHEMBL4855677) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50508775
![PNG](/data/jpeg/tenK5050/BindingDB_50508775.png) (CHEMBL4457636)Show InChI InChI=1S/C16H12ClN3O/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,18,19,21) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TET2 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570896
![PNG](/data/jpeg/tenK5057/BindingDB_50570896.png) (CHEMBL4847806) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570895
![PNG](/data/jpeg/tenK5057/BindingDB_50570895.png) (CHEMBL4859276) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.08E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570892
![PNG](/data/jpeg/tenK5057/BindingDB_50570892.png) (CHEMBL4870693) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.62E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570892
![PNG](/data/jpeg/tenK5057/BindingDB_50570892.png) (CHEMBL4870693) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 3.42E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570893
![PNG](/data/jpeg/tenK5057/BindingDB_50570893.png) (CHEMBL4851104) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570894
![PNG](/data/jpeg/tenK5057/BindingDB_50570894.png) (CHEMBL4855677) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |
Methylcytosine dioxygenase TET2
(Homo sapiens) | BDBM50570895
![PNG](/data/jpeg/tenK5057/BindingDB_50570895.png) (CHEMBL4859276) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116141 BindingDB Entry DOI: 10.7270/Q2GB27V8 |
More data for this Ligand-Target Pair | |