Found 154 hits with Last Name = 'fox' and Initial = 'ae' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368552
(CHEMBL4161036)Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-23(15-22(20)5-6-26-17-34-27-18-33-7-8-38(26)27)28(39)35-25-14-21(13-24(16-25)29(30,31)32)19-37-11-9-36(2)10-12-37/h3-4,7-8,13-18H,9-12,19H2,1-2H3,(H,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368552
(CHEMBL4161036)Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-23(15-22(20)5-6-26-17-34-27-18-33-7-8-38(26)27)28(39)35-25-14-21(13-24(16-25)29(30,31)32)19-37-11-9-36(2)10-12-37/h3-4,7-8,13-18H,9-12,19H2,1-2H3,(H,35,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368552
(CHEMBL4161036)Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-23(15-22(20)5-6-26-17-34-27-18-33-7-8-38(26)27)28(39)35-25-14-21(13-24(16-25)29(30,31)32)19-37-11-9-36(2)10-12-37/h3-4,7-8,13-18H,9-12,19H2,1-2H3,(H,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368455
(CHEMBL4175086)Show SMILES CCc1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-4-5-24(16-23(22)6-7-27-18-35-28-19-34-8-9-39(27)28)29(40)36-26-15-21(14-25(17-26)30(31,32)33)20-38-12-10-37(2)11-13-38/h4-5,8-9,14-19H,3,10-13,20H2,1-2H3,(H,36,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368600
(CHEMBL4164030)Show SMILES CCc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H29F3N6O/c1-3-21-6-7-23(14-22(21)5-4-19-16-33-27(32)34-17-19)26(38)35-25-13-20(12-24(15-25)28(29,30)31)18-37-10-8-36(2)9-11-37/h6-7,12-17H,3,8-11,18H2,1-2H3,(H,35,38)(H2,32,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368547
(CHEMBL4164448)Show SMILES CCc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-6-7-24(17-23(22)8-9-27-19-34-28-5-4-10-35-39(27)28)29(40)36-26-16-21(15-25(18-26)30(31,32)33)20-38-13-11-37(2)12-14-38/h4-7,10,15-19H,3,11-14,20H2,1-2H3,(H,36,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368573
(CHEMBL4174682)Show SMILES CCc1ccc(cc1C#Cc1cnc(NC)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H31F3N6O/c1-4-22-7-8-24(15-23(22)6-5-20-17-34-28(33-2)35-18-20)27(39)36-26-14-21(13-25(16-26)29(30,31)32)19-38-11-9-37(3)10-12-38/h7-8,13-18H,4,9-12,19H2,1-3H3,(H,36,39)(H,33,34,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528533
(CHEMBL4558430)Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368541
(CHEMBL4171640)Show SMILES CCc1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H30F3N5O/c1-3-23-7-8-25(18-24(23)9-10-28-20-35-29-6-4-5-11-39(28)29)30(40)36-27-17-22(16-26(19-27)31(32,33)34)21-38-14-12-37(2)13-15-38/h4-8,11,16-20H,3,12-15,21H2,1-2H3,(H,36,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368455
(CHEMBL4175086)Show SMILES CCc1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-4-5-24(16-23(22)6-7-27-18-35-28-19-34-8-9-39(27)28)29(40)36-26-15-21(14-25(17-26)30(31,32)33)20-38-12-10-37(2)11-13-38/h4-5,8-9,14-19H,3,10-13,20H2,1-2H3,(H,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368551
(CHEMBL4167877)Show SMILES CCc1ccc(cc1C#Cc1cnc(C)n1C)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H32F3N5O/c1-5-22-6-7-24(16-23(22)8-9-27-18-33-20(2)36(27)4)28(38)34-26-15-21(14-25(17-26)29(30,31)32)19-37-12-10-35(3)11-13-37/h6-7,14-18H,5,10-13,19H2,1-4H3,(H,34,38) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368453
(CHEMBL4159558)Show SMILES CCc1ccc(cc1C#Cc1cncnc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H28F3N5O/c1-3-22-6-7-24(14-23(22)5-4-20-16-32-19-33-17-20)27(37)34-26-13-21(12-25(15-26)28(29,30)31)18-36-10-8-35(2)9-11-36/h6-7,12-17,19H,3,8-11,18H2,1-2H3,(H,34,37) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368452
(CHEMBL4168305)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-7-5-24(16-23(28)4-6-27-18-36-29-19-35-8-9-40(27)29)30(41)37-26-15-22(14-25(17-26)31(32,33)34)20-39-12-10-38(3)11-13-39/h5,7-9,14-19,21H,10-13,20H2,1-3H3,(H,37,41) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368455
(CHEMBL4175086)Show SMILES CCc1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-4-5-24(16-23(22)6-7-27-18-35-28-19-34-8-9-39(27)28)29(40)36-26-15-21(14-25(17-26)30(31,32)33)20-38-12-10-37(2)11-13-38/h4-5,8-9,14-19H,3,10-13,20H2,1-2H3,(H,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50430839
(CHEMBL2336015)Show SMILES CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-23-6-7-25(16-24(23)5-4-21-18-34-28-8-9-35-39(28)20-21)29(40)36-27-15-22(14-26(17-27)30(31,32)33)19-38-12-10-37(2)11-13-38/h6-9,14-18,20H,3,10-13,19H2,1-2H3,(H,36,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368541
(CHEMBL4171640)Show SMILES CCc1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H30F3N5O/c1-3-23-7-8-25(18-24(23)9-10-28-20-35-29-6-4-5-11-39(28)29)30(40)36-27-17-22(16-26(19-27)31(32,33)34)21-38-14-12-37(2)13-15-38/h4-8,11,16-20H,3,12-15,21H2,1-2H3,(H,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368555
(CHEMBL4172767)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-9-7-24(17-23(28)6-8-27-19-35-29-5-4-10-36-40(27)29)30(41)37-26-16-22(15-25(18-26)31(32,33)34)20-39-13-11-38(3)12-14-39/h4-5,7,9-10,15-19,21H,11-14,20H2,1-3H3,(H,37,41) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368547
(CHEMBL4164448)Show SMILES CCc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-6-7-24(17-23(22)8-9-27-19-34-28-5-4-10-35-39(27)28)29(40)36-26-16-21(15-25(18-26)30(31,32)33)20-38-13-11-37(2)12-14-38/h4-7,10,15-19H,3,11-14,20H2,1-2H3,(H,36,40) | PDB
MMDB
Reactome pathway
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| PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368550
(CHEMBL4167237)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C32H32F3N5O/c1-22(2)29-10-8-25(18-24(29)7-9-28-20-36-30-6-4-5-11-40(28)30)31(41)37-27-17-23(16-26(19-27)32(33,34)35)21-39-14-12-38(3)13-15-39/h4-6,8,10-11,16-20,22H,12-15,21H2,1-3H3,(H,37,41) | PDB
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PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368547
(CHEMBL4164448)Show SMILES CCc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C30H29F3N6O/c1-3-22-6-7-24(17-23(22)8-9-27-19-34-28-5-4-10-35-39(27)28)29(40)36-26-16-21(15-25(18-26)30(31,32)33)20-38-13-11-37(2)12-14-38/h4-7,10,15-19H,3,11-14,20H2,1-2H3,(H,36,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
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PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368556
(CHEMBL4176145)Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C4CC4)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1 Show InChI InChI=1S/C31H29F3N6O/c1-38-10-12-39(13-11-38)20-21-14-25(31(32,33)34)17-26(15-21)37-30(41)24-5-7-28(22-2-3-22)23(16-24)4-6-27-18-36-29-19-35-8-9-40(27)29/h5,7-9,14-19,22H,2-3,10-13,20H2,1H3,(H,37,41) | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528542
(CHEMBL4472004)Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528539
(CHEMBL4553037)Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1 | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528538
(CHEMBL4541139)Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r| Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1 | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528541
(CHEMBL4437631)Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1 | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50368548
(CHEMBL4159956)Show SMILES CCc1ccc(cc1C#Cc1cncn1C)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H30F3N5O/c1-4-21-5-6-23(15-22(21)7-8-26-17-32-19-35(26)3)27(37)33-25-14-20(13-24(16-25)28(29,30)31)18-36-11-9-34(2)10-12-36/h5-6,13-17,19H,4,9-12,18H2,1-3H3,(H,33,37) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR1 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528528
(CHEMBL4441609)Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r| Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1 | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
NT-3 growth factor receptor
(Homo sapiens (Human)) | BDBM50368452
(CHEMBL4168305)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-7-5-24(16-23(28)4-6-27-18-36-29-19-35-8-9-40(27)29)30(41)37-26-15-22(14-25(17-26)31(32,33)34)20-39-12-10-38(3)11-13-39/h5,7-9,14-19,21H,10-13,20H2,1-3H3,(H,37,41) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of TrkC (unknown origin) by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368452
(CHEMBL4168305)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-7-5-24(16-23(28)4-6-27-18-36-29-19-35-8-9-40(27)29)30(41)37-26-15-22(14-25(17-26)31(32,33)34)20-39-12-10-38(3)11-13-39/h5,7-9,14-19,21H,10-13,20H2,1-3H3,(H,37,41) | PDB
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PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368541
(CHEMBL4171640)Show SMILES CCc1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H30F3N5O/c1-3-23-7-8-25(18-24(23)9-10-28-20-35-29-6-4-5-11-39(28)29)30(40)36-27-17-22(16-26(19-27)31(32,33)34)21-38-14-12-37(2)13-15-38/h4-8,11,16-20H,3,12-15,21H2,1-2H3,(H,36,40) | PDB
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PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368600
(CHEMBL4164030)Show SMILES CCc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H29F3N6O/c1-3-21-6-7-23(14-22(21)5-4-19-16-33-27(32)34-17-19)26(38)35-25-13-20(12-24(15-25)28(29,30)31)18-37-10-8-36(2)9-11-37/h6-7,12-17H,3,8-11,18H2,1-2H3,(H,35,38)(H2,32,33,34) | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50528533
(CHEMBL4558430)Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1 | PDB
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368573
(CHEMBL4174682)Show SMILES CCc1ccc(cc1C#Cc1cnc(NC)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H31F3N6O/c1-4-22-7-8-24(15-23(22)6-5-20-17-34-28(33-2)35-18-20)27(39)36-26-14-21(13-25(16-26)29(30,31)32)19-38-11-9-37(3)10-12-38/h7-8,13-18H,4,9-12,19H2,1-3H3,(H,36,39)(H,33,34,35) | PDB
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PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
NT-3 growth factor receptor
(Homo sapiens (Human)) | BDBM50528539
(CHEMBL4553037)Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1 | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368551
(CHEMBL4167877)Show SMILES CCc1ccc(cc1C#Cc1cnc(C)n1C)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H32F3N5O/c1-5-22-6-7-24(16-23(22)8-9-27-18-33-20(2)36(27)4)28(38)34-26-15-21(14-25(17-26)29(30,31)32)19-37-12-10-35(3)11-13-37/h6-7,14-18H,5,10-13,19H2,1-4H3,(H,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human)) | BDBM50528539
(CHEMBL4553037)Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human)) | BDBM50368452
(CHEMBL4168305)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cnccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-7-5-24(16-23(28)4-6-27-18-36-29-19-35-8-9-40(27)29)30(41)37-26-15-22(14-25(17-26)31(32,33)34)20-39-12-10-38(3)11-13-39/h5,7-9,14-19,21H,10-13,20H2,1-3H3,(H,37,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of TrkB (unknown origin) by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368556
(CHEMBL4176145)Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C4CC4)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1 Show InChI InChI=1S/C31H29F3N6O/c1-38-10-12-39(13-11-38)20-21-14-25(31(32,33)34)17-26(15-21)37-30(41)24-5-7-28(22-2-3-22)23(16-24)4-6-27-18-36-29-19-35-8-9-40(27)29/h5,7-9,14-19,22H,2-3,10-13,20H2,1H3,(H,37,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528535
(CHEMBL4472914)Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368600
(CHEMBL4164030)Show SMILES CCc1ccc(cc1C#Cc1cnc(N)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H29F3N6O/c1-3-21-6-7-23(14-22(21)5-4-19-16-33-27(32)34-17-19)26(38)35-25-13-20(12-24(15-25)28(29,30)31)18-37-10-8-36(2)9-11-37/h6-7,12-17H,3,8-11,18H2,1-2H3,(H,35,38)(H2,32,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
NT-3 growth factor receptor
(Homo sapiens (Human)) | BDBM50528535
(CHEMBL4472914)Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368555
(CHEMBL4172767)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C31H31F3N6O/c1-21(2)28-9-7-24(17-23(28)6-8-27-19-35-29-5-4-10-36-40(27)29)30(41)37-26-16-22(15-25(18-26)31(32,33)34)20-39-13-11-38(3)12-14-39/h4-5,7,9-10,15-19,21H,11-14,20H2,1-3H3,(H,37,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368550
(CHEMBL4167237)Show SMILES CC(C)c1ccc(cc1C#Cc1cnc2ccccn12)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C32H32F3N5O/c1-22(2)29-10-8-25(18-24(29)7-9-28-20-36-30-6-4-5-11-40(28)30)31(41)37-27-17-23(16-26(19-27)32(33,34)35)21-39-14-12-38(3)13-15-39/h4-6,8,10-11,16-20,22H,12-15,21H2,1-3H3,(H,37,41) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50528539
(CHEMBL4553037)Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM50528536
(CHEMBL4560079)Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)-n1cnc(C)c1)C1CCCCC1)c1cncnc1 |r| Show InChI InChI=1S/C31H34N6O/c1-21-18-37(20-34-21)29-14-26(22-6-4-3-5-7-22)11-27(15-29)35-31(38)24-9-8-23-12-28(13-25(23)10-24)36(2)30-16-32-19-33-17-30/h8-11,14-20,22,28H,3-7,12-13H2,1-2H3,(H,35,38)/t28-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368573
(CHEMBL4174682)Show SMILES CCc1ccc(cc1C#Cc1cnc(NC)nc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H31F3N6O/c1-4-22-7-8-24(15-23(22)6-5-20-17-34-28(33-2)35-18-20)27(39)36-26-14-21(13-25(16-26)29(30,31)32)19-38-11-9-37(3)10-12-38/h7-8,13-18H,4,9-12,19H2,1-3H3,(H,36,39)(H,33,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50368548
(CHEMBL4159956)Show SMILES CCc1ccc(cc1C#Cc1cncn1C)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H30F3N5O/c1-4-21-5-6-23(15-22(21)7-8-26-17-32-19-35(26)3)27(37)33-25-14-20(13-24(16-25)28(29,30)31)18-36-11-9-34(2)10-12-36/h5-6,13-17,19H,4,9-12,18H2,1-3H3,(H,33,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50368551
(CHEMBL4167877)Show SMILES CCc1ccc(cc1C#Cc1cnc(C)n1C)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F Show InChI InChI=1S/C29H32F3N5O/c1-5-22-6-7-24(16-23(22)8-9-27-18-33-20(2)36(27)4)28(38)34-26-15-21(14-25(17-26)29(30,31)32)19-37-12-10-35(3)11-13-37/h6-7,14-18H,5,10-13,19H2,1-4H3,(H,34,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of Abl1 (unknown origin) incubated for 1 hr in presence of Tyrosine-2 peptide substrate by FRET based Z'-Lyte assay |
J Med Chem 61: 7977-7990 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01045
BindingDB Entry DOI: 10.7270/Q24Q7XHN |
More data for this
Ligand-Target Pair | |
Discoidin domain-containing receptor 2
(Homo sapiens (Human)) | BDBM50528542
(CHEMBL4472004)Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r| Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
BDNF/NT-3 growth factors receptor
(Homo sapiens (Human)) | BDBM50528528
(CHEMBL4441609)Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r| Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass... |
J Med Chem 62: 7431-7444 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV |
More data for this
Ligand-Target Pair | |
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