BindingDB PrimarySearch

BDBM50528539 CHEMBL4553037

SMILES: C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1

InChI Key: InChIKey=CMJJZRAAQMUAFH-INIZCTEOSA-N

Data: 11 IC50 16 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50528539
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscle, skeletal receptor tyrosine protein kinase (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length MUSK (553 to 869 residues) expressed in bacterial expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to TrkB (unknown origin)				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKB (547 to 838 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged DDR1 (440 to 876 residues) expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT a...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length EPHA8 (608 to 920 residues) expressed in bacterial expression system preincubated for 1 hr measure...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
PITSLRE serine/threonine-protein kinase CDC2L1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length CDK11 (1 to 360 residues) expressed in bacterial expression system preincubated for 1 hr measured ...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKA (475 to 790 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human full length recombinant His-tagged ABL1 expressed in baculovirus infected Sf9 insect cells using tyrosine 2 peptide as substrate ...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged DDR2 expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT as substrate preincubat...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length DDR1 (565 to 876 residues) expressed in bacterial expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
PITSLRE serine/threonine-protein kinase CDC2L1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length CDK11 (1 to 360 residues) expressed in bacterial expression system preincubated for 1 hr measured ...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Ephrin receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length EPHA8 (608 to 920 residues) expressed in bacterial expression system preincubated for 1 hr measure...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKC (531 to 825 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length DDR1 (565 to 876 residues) expressed in bacterial expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Muscle, skeletal receptor tyrosine protein kinase (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length MUSK (553 to 869 residues) expressed in bacterial expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length TRKA (475 to 790 residues) expressed in mammalian expression system preincubated for 1 hr measured...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human full length recombinant His-tagged ABL1 expressed in baculovirus infected Sf9 insect cells using tyrosine 2 peptide as substrate ...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged DDR2 expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT as substrate preincubat...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to TrkC (unknown origin)				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...				J Med Chem 62: 7431-7444 (2019) Article DOI: 10.1021/acs.jmedchem.9b00365
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50528539 (CHEMBL4553037) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged DDR1 (440 to 876 residues) expressed in baculovirus infected Sf9 insect cells using fluorescein-poly GAT a...				J Med Chem 59: 5911-6 (2016) Article DOI: 10.1021/acs.jmedchem.6b00140
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair