Compile Data Set for Download or QSAR

Found 138 hits with Last Name = 'patron' and Initial = 'ap'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211262 (US9247759, 10-10) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(O)c2)C1=O Show InChI InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-4-3-5-16(25)6-14/h3-7,9,25H,8,10-11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211356 (US9247759, 12-7) Show SMILES C[C@H]1N(Cc2cccc(O)c2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r| Show InChI InChI=1S/C20H21N5O4/c1-12-18(14(3)29-22-12)11-23-10-16(8-21-23)25-19(27)13(2)24(20(25)28)9-15-5-4-6-17(26)7-15/h4-8,10,13,26H,9,11H2,1-3H3/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211355 (US9247759, 12-6) Show SMILES C[C@@H]1N(Cc2cccc(O)c2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r| Show InChI InChI=1S/C20H21N5O4/c1-12-18(14(3)29-22-12)11-23-10-16(8-21-23)25-19(27)13(2)24(20(25)28)9-15-5-4-6-17(26)7-15/h4-8,10,13,26H,9,11H2,1-3H3/t13-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211364 (US9247759, 12-15) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CC2)C1=O Show InChI InChI=1S/C21H21N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(6-7-21)25(20(26)29)10-15-4-3-5-17(27)8-15/h3-5,8-9,11,27H,6-7,10,12H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211264 (US9247759, 10-12) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccc(O)cc2)C1=O Show InChI InChI=1S/C19H19N5O4/c1-12-17(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-3-5-16(25)6-4-14/h3-7,9,25H,8,10-11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211358 (US9247759, 12-9) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)[C@H](CO)N(Cc2cccc(O)c2)C1=O |r| Show InChI InChI=1S/C20H21N5O5/c1-12-17(13(2)30-22-12)10-23-9-15(7-21-23)25-19(28)18(11-26)24(20(25)29)8-14-4-3-5-16(27)6-14/h3-7,9,18,26-27H,8,10-11H2,1-2H3/t18-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211353 (US9247759, 12-4) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CCC2)C1=O Show InChI InChI=1S/C22H23N5O4/c1-14-19(15(2)31-24-14)13-25-12-17(10-23-25)27-20(29)22(7-4-8-22)26(21(27)30)11-16-5-3-6-18(28)9-16/h3,5-6,9-10,12,28H,4,7-8,11,13H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211350 (US9247759, 12-1) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C(C)(C)C1=O Show InChI InChI=1S/C21H23N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(3,4)25(20(26)29)10-15-6-5-7-17(27)8-15/h5-9,11,27H,10,12H2,1-4H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211359 (US9247759, 12-10) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C(C)(CO)C1=O Show InChI InChI=1S/C21H23N5O5/c1-13-18(14(2)31-23-13)11-24-10-16(8-22-24)26-19(29)21(3,12-27)25(20(26)30)9-15-5-4-6-17(28)7-15/h4-8,10,27-28H,9,11-12H2,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211272 (US9247759, 10-20) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2C)C1=O Show InChI InChI=1S/C20H21N5O3/c1-13-6-4-5-7-16(13)9-23-12-19(26)25(20(23)27)17-8-21-24(10-17)11-18-14(2)22-28-15(18)3/h4-8,10H,9,11-12H2,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211270 (US9247759, 10-18) Show SMILES COc1ccccc1CN1CC(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C20H21N5O4/c1-13-17(14(2)29-22-13)11-24-10-16(8-21-24)25-19(26)12-23(20(25)27)9-15-6-4-5-7-18(15)28-3/h4-8,10H,9,11-12H2,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211263 (US9247759, 10-11) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2O)C1=O Show InChI InChI=1S/C19H19N5O4/c1-12-16(13(2)28-21-12)10-23-9-15(7-20-23)24-18(26)11-22(19(24)27)8-14-5-3-4-6-17(14)25/h3-7,9,25H,8,10-11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211259 (US9247759, 10-7) Show SMILES COC(=O)c1cccc(CN2CC(=O)N(C2=O)c2cnn(Cc3c(C)noc3C)c2)c1 Show InChI InChI=1S/C21H21N5O5/c1-13-18(14(2)31-23-13)11-25-10-17(8-22-25)26-19(27)12-24(21(26)29)9-15-5-4-6-16(7-15)20(28)30-3/h4-8,10H,9,11-12H2,1-3H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211273 (US9247759, 10-21) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2F)C1=O Show InChI InChI=1S/C19H18FN5O3/c1-12-16(13(2)28-22-12)10-24-9-15(7-21-24)25-18(26)11-23(19(25)27)8-14-5-3-4-6-17(14)20/h3-7,9H,8,10-11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211261 (US9247759, 10-9) Show SMILES CNC(=O)c1cccc(CN2CC(=O)N(C2=O)c2cnn(Cc3c(C)noc3C)c2)c1 Show InChI InChI=1S/C21H22N6O4/c1-13-18(14(2)31-24-13)11-26-10-17(8-23-26)27-19(28)12-25(21(27)30)9-15-5-4-6-16(7-15)20(29)22-3/h4-8,10H,9,11-12H2,1-3H3,(H,22,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211244 (US9247759, 9-1) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C17H14N4O3/c1-10-15(11(2)24-19-10)9-20-8-12(7-18-20)21-16(22)13-5-3-4-6-14(13)17(21)23/h3-8H,9H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210974 (US9247759, 4-8) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccc3OCOc3c2)cn1 Show InChI InChI=1S/C17H16N4O4/c1-10-14(11(2)25-20-10)8-21-7-13(6-18-21)19-17(22)12-3-4-15-16(5-12)24-9-23-15/h3-7H,8-9H2,1-2H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511890 (CHEMBL4514970) Show SMILES Cc1cc(CN2CC(=O)N(C2=O)c2cnn(Cc3c(C)noc3C)c2)n(C)n1 Show InChI InChI=1S/C18H21N7O3/c1-11-5-14(22(4)20-11)7-23-10-17(26)25(18(23)27)15-6-19-24(8-15)9-16-12(2)21-28-13(16)3/h5-6,8H,7,9-10H2,1-4H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211305 (US9247759, 10-53 | US9247759, 10-88) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2)C1=O Show InChI InChI=1S/C19H19N5O3/c1-13-17(14(2)27-21-13)11-23-10-16(8-20-23)24-18(25)12-22(19(24)26)9-15-6-4-3-5-7-15/h3-8,10H,9,11-12H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511886 (CHEMBL4452065) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccc3[nH]ccc3c2)cn1 Show InChI InChI=1S/C18H17N5O2/c1-11-16(12(2)25-22-11)10-23-9-15(8-20-23)21-18(24)14-3-4-17-13(7-14)5-6-19-17/h3-9,19H,10H2,1-2H3,(H,21,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211326 (US9247759, 10-74) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(CC2CCCCC2)C1=O Show InChI InChI=1S/C19H25N5O3/c1-13-17(14(2)27-21-13)11-23-10-16(8-20-23)24-18(25)12-22(19(24)26)9-15-6-4-3-5-7-15/h8,10,15H,3-7,9,11-12H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211285 (US9247759, 10-33) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(CO)c2)C1=O Show InChI InChI=1S/C20H21N5O4/c1-13-18(14(2)29-22-13)10-24-9-17(7-21-24)25-19(27)11-23(20(25)28)8-15-4-3-5-16(6-15)12-26/h3-7,9,26H,8,10-12H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210975 (US9247759, 4-9) Show SMILES COc1ccc(OC)c(c1)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C18H20N4O4/c1-11-16(12(2)26-21-11)10-22-9-13(8-19-22)20-18(23)15-7-14(24-3)5-6-17(15)25-4/h5-9H,10H2,1-4H3,(H,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211052 (US9247759, 4-88) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccc3OCCOc3c2)cn1 Show InChI InChI=1S/C18H18N4O4/c1-11-15(12(2)26-21-11)10-22-9-14(8-19-22)20-18(23)13-3-4-16-17(7-13)25-6-5-24-16/h3-4,7-9H,5-6,10H2,1-2H3,(H,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511892 (CHEMBL4469393) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2cccc(O)c2)cn1 Show InChI InChI=1S/C16H16N4O3/c1-10-15(11(2)23-19-10)9-20-8-13(7-17-20)18-16(22)12-4-3-5-14(21)6-12/h3-8,21H,9H2,1-2H3,(H,18,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211020 (US9247759, 4-55) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)CCc2ccccc2)cn1 Show InChI InChI=1S/C18H20N4O2/c1-13-17(14(2)24-21-13)12-22-11-16(10-19-22)20-18(23)9-8-15-6-4-3-5-7-15/h3-7,10-11H,8-9,12H2,1-2H3,(H,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211307 (US9247759, 10-55) Show SMILES Cc1noc(C)c1CN1CC(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C18H20N6O4/c1-10-15(12(3)27-20-10)7-22-9-17(25)24(18(22)26)14-5-19-23(6-14)8-16-11(2)21-28-13(16)4/h5-6H,7-9H2,1-4H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211271 (US9247759, 10-19) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccc2C#N)C1=O Show InChI InChI=1S/C20H18N6O3/c1-13-18(14(2)29-23-13)11-25-10-17(8-22-25)26-19(27)12-24(20(26)28)9-16-6-4-3-5-15(16)7-21/h3-6,8,10H,9,11-12H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511893 (CHEMBL4567380) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccc(O)cc2)cn1 Show InChI InChI=1S/C16H16N4O3/c1-10-15(11(2)23-19-10)9-20-8-13(7-17-20)18-16(22)12-3-5-14(21)6-4-12/h3-8,21H,9H2,1-2H3,(H,18,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210973 (US9247759, 4-7 | US9247759, compound B) Show SMILES COc1cccc(c1)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C17H18N4O3/c1-11-16(12(2)24-20-11)10-21-9-14(8-18-21)19-17(22)13-5-4-6-15(7-13)23-3/h4-9H,10H2,1-3H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210983 (US9247759, 4-17) Show SMILES COc1ccc(cc1)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C17H18N4O3/c1-11-16(12(2)24-20-11)10-21-9-14(8-18-21)19-17(22)13-4-6-15(23-3)7-5-13/h4-9H,10H2,1-3H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511894 (CHEMBL4447100) Show SMILES COc1cccc(n1)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C16H17N5O3/c1-10-13(11(2)24-20-10)9-21-8-12(7-17-21)18-16(22)14-5-4-6-15(19-14)23-3/h4-8H,9H2,1-3H3,(H,18,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511888 (CHEMBL4456506) Show SMILES COc1cncc(c1)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C16H17N5O3/c1-10-15(11(2)24-20-10)9-21-8-13(6-18-21)19-16(22)12-4-14(23-3)7-17-5-12/h4-8H,9H2,1-3H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211021 (US9247759, 4-56) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)CCCc2ccccc2)cn1 Show InChI InChI=1S/C19H22N4O2/c1-14-18(15(2)25-22-14)13-23-12-17(11-20-23)21-19(24)10-6-9-16-7-4-3-5-8-16/h3-5,7-8,11-12H,6,9-10,13H2,1-2H3,(H,21,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210972 (US9247759, 4-6) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)Cc2ccccc2)cn1 Show InChI InChI=1S/C17H18N4O2/c1-12-16(13(2)23-20-12)11-21-10-15(9-18-21)19-17(22)8-14-6-4-3-5-7-14/h3-7,9-10H,8,11H2,1-2H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211253 (US9247759, 10-1) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CNC1=O Show InChI InChI=1S/C12H13N5O3/c1-7-10(8(2)20-15-7)6-16-5-9(3-14-16)17-11(18)4-13-12(17)19/h3,5H,4,6H2,1-2H3,(H,13,19)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211306 (US9247759, 10-54) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2ccccn2)C1=O Show InChI InChI=1S/C18H18N6O3/c1-12-16(13(2)27-21-12)10-23-9-15(7-20-23)24-17(25)11-22(18(24)26)8-14-5-3-4-6-19-14/h3-7,9H,8,10-11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511891 (CHEMBL4530528) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1CCN(Cc2ccccc2)C1=O Show InChI InChI=1S/C19H21N5O2/c1-14-18(15(2)26-21-14)13-23-12-17(10-20-23)24-9-8-22(19(24)25)11-16-6-4-3-5-7-16/h3-7,10,12H,8-9,11,13H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511896 (CHEMBL4526144) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)NCc2ccccc2)cn1 Show InChI InChI=1S/C17H19N5O2/c1-12-16(13(2)24-21-12)11-22-10-15(9-19-22)20-17(23)18-8-14-6-4-3-5-7-14/h3-7,9-10H,8,11H2,1-2H3,(H2,18,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210987 (US9247759, 4-21) Show SMILES COc1ccc(cc1OC)C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C18H20N4O4/c1-11-15(12(2)26-21-11)10-22-9-14(8-19-22)20-18(23)13-5-6-16(24-3)17(7-13)25-4/h5-9H,10H2,1-4H3,(H,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511887 (CHEMBL4588973) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccccc2O)cn1 Show InChI InChI=1S/C16H16N4O3/c1-10-14(11(2)23-19-10)9-20-8-12(7-17-20)18-16(22)13-5-3-4-6-15(13)21/h3-8,21H,9H2,1-2H3,(H,18,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211325 (US9247759, 10-73) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(CC2CCCO2)C1=O Show InChI InChI=1S/C17H21N5O4/c1-11-15(12(2)26-19-11)9-21-7-13(6-18-21)22-16(23)10-20(17(22)24)8-14-4-3-5-25-14/h6-7,14H,3-5,8-10H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211011 (US9247759, 4-46) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2cccnc2)cn1 Show InChI InChI=1S/C15H15N5O2/c1-10-14(11(2)22-19-10)9-20-8-13(7-17-20)18-15(21)12-4-3-5-16-6-12/h3-8H,9H2,1-2H3,(H,18,21)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511889 (CHEMBL4579065) Show SMILES COc1ncccc1C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C16H17N5O3/c1-10-14(11(2)24-20-10)9-21-8-12(7-18-21)19-15(22)13-5-4-6-17-16(13)23-3/h4-8H,9H2,1-3H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210989 (US9247759, 4-24) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)c2ccccc2)cn1 Show InChI InChI=1S/C16H16N4O2/c1-11-15(12(2)22-19-11)10-20-9-14(8-17-20)18-16(21)13-6-4-3-5-7-13/h3-9H,10H2,1-2H3,(H,18,21)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM210985 (US9247759, 4-19) Show SMILES COc1ccccc1C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C17H18N4O3/c1-11-15(12(2)24-20-11)10-21-9-13(8-18-21)19-17(22)14-6-4-5-7-16(14)23-3/h4-9H,10H2,1-3H3,(H,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511885 (CHEMBL4443466) Show SMILES Cc1noc(C)c1Cn1cc(NC(=O)Nc2ccccc2)cn1 Show InChI InChI=1S/C16H17N5O2/c1-11-15(12(2)23-20-11)10-21-9-14(8-17-21)19-16(22)18-13-6-4-3-5-7-13/h3-9H,10H2,1-2H3,(H2,18,19,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511884 (CHEMBL4471870) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2ccccc2)C(=O)C1=O Show InChI InChI=1S/C19H17N5O4/c1-12-16(13(2)28-21-12)11-22-10-15(8-20-22)24-18(26)17(25)23(19(24)27)9-14-6-4-3-5-7-14/h3-8,10H,9,11H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM211260 (US9247759, 10-8) Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(c2)C(O)=O)C1=O Show InChI InChI=1S/C20H19N5O5/c1-12-17(13(2)30-22-12)10-24-9-16(7-21-24)25-18(26)11-23(20(25)29)8-14-4-3-5-15(6-14)19(27)28/h3-7,9H,8,10-11H2,1-2H3,(H,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair
Taste receptor type 2 member 8 (Homo sapiens (Human))	BDBM50511895 (CHEMBL4448191) Show SMILES CCSc1ncccc1C(=O)Nc1cnn(Cc2c(C)noc2C)c1 Show InChI InChI=1S/C17H19N5O2S/c1-4-25-17-14(6-5-7-18-17)16(23)20-13-8-19-22(9-13)10-15-11(2)21-24-12(15)3/h5-9H,4,10H2,1-3H3,(H,20,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Firmenich SA Curated by ChEMBL					Assay Description Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...				J Med Chem 63: 4957-4977 (2020) Article DOI: 10.1021/acs.jmedchem.0c00388 BindingDB Entry DOI: 10.7270/Q2VH5S56
					More data for this Ligand-Target Pair

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