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Found 2 hits Enz. Inhib. hit(s) with Target = 'Taste receptor type 2 member 8' and Ligand = 'BDBM211364'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211364
PNG
(US9247759, 12-15)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CC2)C1=O
Show InChI InChI=1S/C21H21N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(6-7-21)25(20(26)29)10-15-4-3-5-17(27)8-15/h3-5,8-9,11,27H,6-7,10,12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Firmenich SA

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TAS2R8 stably expressed in cells co-expressing Galpha16gust44 assessed as inhibition of andrographolide-indu...

J Med Chem 63: 4957-4977 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00388
BindingDB Entry DOI: 10.7270/Q2VH5S56
More data for this
Ligand-Target Pair
Taste receptor type 2 member 8


(Homo sapiens (Human))		BDBM211364
PNG
(US9247759, 12-15)
Show SMILES Cc1noc(C)c1Cn1cc(cn1)N1C(=O)N(Cc2cccc(O)c2)C2(CC2)C1=O
Show InChI InChI=1S/C21H21N5O4/c1-13-18(14(2)30-23-13)12-24-11-16(9-22-24)26-19(28)21(6-7-21)25(20(26)29)10-15-4-3-5-17(27)8-15/h3-5,8-9,11,27H,6-7,10,12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



Senomyx, Inc.

US Patent


Assay Description
In another embodiment, Fluorescence Polarization ("FP") based assays may be used to detect and monitor ligand binding. Fluorescence polarization is a...

US Patent US9247759 (2016)


BindingDB Entry DOI: 10.7270/Q2V69HFW
More data for this
Ligand-Target Pair