Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543845![]() (CHEMBL4643623) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50534427![]() (CHEMBL4437824) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543843![]() (CHEMBL4636872) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50171513![]() ((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50171511![]() ((S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543844![]() (CHEMBL4645676) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543847![]() (CHEMBL4638232) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM66082![]() ((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of DHFR in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543846![]() (CHEMBL4641908) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM66082![]() ((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of DHFR in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by Cell-... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543848![]() (CHEMBL4642637) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of DHFR in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 327 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of DHFR in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by Cell-... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50534427![]() (CHEMBL4437824) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 666 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543845![]() (CHEMBL4643623) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 757 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543848![]() (CHEMBL4642637) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50171511![]() ((S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50171513![]() ((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543846![]() (CHEMBL4641908) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543844![]() (CHEMBL4645676) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543843![]() (CHEMBL4636872) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human)) | BDBM50543847![]() (CHEMBL4638232) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of GARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as reduction in cell growth after 96 hrs in presence of folic acid by C... | Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115544 BindingDB Entry DOI: 10.7270/Q29Z98G2 | |||||||||||
More data for this Ligand-Target Pair |