Found 421 hits with Last Name = 'youngblood' and Initial = 'bd' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463853
(CHEMBL4237618)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C19H12F5N3O2/c20-13-2-1-7-25-17(13)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-12(14(21)8-10)19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463854
(CHEMBL4251427)Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc(=O)[nH]c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C20H13F6N3O2/c21-19(22,23)13-6-3-11(4-7-13)16(17-14(20(24,25)26)2-1-9-27-17)29-18(31)12-5-8-15(30)28-10-12/h1-10,16H,(H,28,30)(H,29,31)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Mus musculus) | BDBM50463844
(CHEMBL4247840)Show SMILES Oc1ccc(cc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H14F6N2O2/c22-20(23,24)14-7-3-12(4-8-14)17(18-16(21(25,26)27)2-1-11-28-18)29-19(31)13-5-9-15(30)10-6-13/h1-11,17,30H,(H,29,31)/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463853
(CHEMBL4237618)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C19H12F5N3O2/c20-13-2-1-7-25-17(13)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-12(14(21)8-10)19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444954
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1cccnn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C25H19F5N6O5S/c1-31-24(37)36(23-8-6-15(13-32-23)42(38,39)35-22-4-3-9-33-34-22)19-12-18(27)16(11-21(19)40-2)14-5-7-17(26)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,34,35) | PDB
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444937
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C25H19ClF4N6O5S/c1-31-24(37)36(22-7-5-15(13-34-22)42(38,39)35-23-32-8-3-9-33-23)19-12-17(26)16(11-21(19)40-2)14-4-6-18(27)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35) | PDB
KEGG
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B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444965
(6-((1-(2-chloro-5-methoxy-3'-(trifluoromethyl)-[1,...)Show SMILES COc1cc(c(Cl)cc1N(C(N)=O)c1ccc(cn1)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17ClF3N5O5S/c1-36-19-10-16(13-3-2-4-14(9-13)23(25,26)27)17(24)11-18(19)32(22(28)33)21-6-5-15(12-29-21)38(34,35)31-20-7-8-37-30-20/h2-12H,1H3,(H2,28,33)(H,30,31) | PDB
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| PC cid
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| Article
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217544
(US9212182, 508 | US9212182, 509)Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(c1)C#N |(-1.33,-5.39,;,-4.62,;1.33,-5.39,;1.33,-6.93,;2.67,-7.7,;4,-6.93,;5.33,-7.7,;4,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;2.67,-12.32,;2.67,-13.86,;4,-11.55,;4,-10.01,;5.33,-12.32,;6.67,-13.09,)| Show InChI InChI=1S/C26H16ClFN4O5S/c1-36-24-12-19(15-2-5-20(27)17(10-15)14-29)21(28)13-23(24)32-22-6-4-18(11-16(22)3-7-26(32)33)38(34,35)31-25-8-9-37-30-25/h2-13H,1H3,(H,30,31) | PDB
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| PC cid
PC sid
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| Article
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463844
(CHEMBL4247840)Show SMILES Oc1ccc(cc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H14F6N2O2/c22-20(23,24)14-7-3-12(4-8-14)17(18-16(21(25,26)27)2-1-11-28-18)29-19(31)13-5-9-15(30)10-6-13/h1-11,17,30H,(H,29,31)/t17-/m0/s1 | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463846
(CHEMBL4243837)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(OC(F)(F)F)c(F)c1 |r| Show InChI InChI=1S/C19H12F5N3O3/c20-12-2-1-7-25-17(12)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-14(13(21)8-10)30-19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM154245
(US9012443, 261)Show SMILES COc1cc(ccc1-c1ncnc2cc(ccc12)S(=O)(=O)Nc1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26) | PDB
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MCE
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| Article
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -60 mV measured for 3 to 5 mins... |
ACS Med Chem Lett 7: 1062-1067 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00243
BindingDB Entry DOI: 10.7270/Q2VM4F65 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Mus musculus) | BDBM50463846
(CHEMBL4243837)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(OC(F)(F)F)c(F)c1 |r| Show InChI InChI=1S/C19H12F5N3O3/c20-12-2-1-7-25-17(12)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-14(13(21)8-10)30-19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463863
(CHEMBL4251467)Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H13F6N3O3/c22-20(23,24)13-6-3-11(4-7-13)16(17-14(21(25,26)27)2-1-9-28-17)30-18(31)15-8-5-12(10-29-15)19(32)33/h1-10,16H,(H,30,31)(H,32,33)/t16-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463855
(CHEMBL4248077)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1 | PDB
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| PC cid
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| Article
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50157631
(CHEMBL3785736)Show SMILES Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of hypo osm... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217455
(US9212182, 431)Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;1.33,-6.93,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;2.67,-12.32,;2.67,-13.86,;4,-11.55,;5.33,-12.32,;4,-10.01,)| Show InChI InChI=1S/C26H20ClN3O5S/c1-16-13-17(3-7-21(16)27)18-4-8-23(24(15-18)34-2)30-22-9-6-20(14-19(22)5-10-26(30)31)36(32,33)29-25-11-12-35-28-25/h3-15H,1-2H3,(H,28,29) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50008716
(CHEMBL3235983)Show SMILES C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(c(F)c1)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H17F7N2O/c1-11(19(22,23)24)28-18(30)29-9-8-12-4-2-3-5-14(12)17(29)13-6-7-15(16(21)10-13)20(25,26)27/h2-7,10-11,17H,8-9H2,1H3,(H,28,30)/t11-,17+/m0/s1 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometry |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217481
(US9212182, 469 | US9212182, 470)Show SMILES COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(Cl)c(C)c1 |(-1.33,-5.39,;,-4.62,;1.33,-5.39,;1.33,-6.93,;2.67,-7.7,;4,-6.93,;5.33,-7.7,;4,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;2.67,-12.32,;2.67,-13.86,;4,-11.55,;5.33,-12.32,;4,-10.01,)| Show InChI InChI=1S/C26H19ClFN3O5S/c1-15-11-16(3-6-20(15)27)19-13-24(35-2)23(14-21(19)28)31-22-7-5-18(12-17(22)4-8-26(31)32)37(33,34)30-25-9-10-36-29-25/h3-14H,1-2H3,(H,29,30) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444876
(6-((2-chloro-5-methoxy-3'-(2,2,2-trifluoroethoxy)-...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(OCC(F)(F)F)c1 Show InChI InChI=1S/C25H21ClF3N5O6S/c1-30-24(35)34(23-7-6-17(13-31-23)41(36,37)33-22-8-9-40-32-22)20-12-19(26)18(11-21(20)38-2)15-4-3-5-16(10-15)39-14-25(27,28)29/h3-13H,14H2,1-2H3,(H,30,35)(H,32,33) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444875
(6-((2-chloro-3',5-dimethoxy-5'-(trifluoromethyl)-4...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cc(OC)cc(c1)C(F)(F)F Show InChI InChI=1S/C25H21ClF3N5O6S/c1-30-24(35)34(23-5-4-17(13-31-23)41(36,37)33-22-6-7-40-32-22)20-12-19(26)18(11-21(20)39-3)14-8-15(25(27,28)29)10-16(9-14)38-2/h4-13H,1-3H3,(H,30,35)(H,32,33) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463854
(CHEMBL4251427)Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc(=O)[nH]c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C20H13F6N3O2/c21-19(22,23)13-6-3-11(4-7-13)16(17-14(20(24,25)26)2-1-9-27-17)29-18(31)12-5-8-15(30)28-10-12/h1-10,16H,(H,28,30)(H,29,31)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50008717
(CHEMBL3235984)Show SMILES C[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(c(F)c1)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C19H16F7N3O/c1-10(18(21,22)23)28-17(30)29-8-6-11-3-2-7-27-15(11)16(29)12-4-5-13(14(20)9-12)19(24,25)26/h2-5,7,9-10,16H,6,8H2,1H3,(H,28,30)/t10-,16+/m0/s1 | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometry |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50008717
(CHEMBL3235984)Show SMILES C[C@H](NC(=O)N1CCc2cccnc2[C@H]1c1ccc(c(F)c1)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C19H16F7N3O/c1-10(18(21,22)23)28-17(30)29-8-6-11-3-2-7-27-15(11)16(29)12-4-5-13(14(20)9-12)19(24,25)26/h2-5,7,9-10,16H,6,8H2,1H3,(H,28,30)/t10-,16+/m0/s1 | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometry |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463846
(CHEMBL4243837)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(OC(F)(F)F)c(F)c1 |r| Show InChI InChI=1S/C19H12F5N3O3/c20-12-2-1-7-25-17(12)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-14(13(21)8-10)30-19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463863
(CHEMBL4251467)Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H13F6N3O3/c22-20(23,24)13-6-3-11(4-7-13)16(17-14(21(25,26)27)2-1-9-28-17)30-18(31)15-8-5-12(10-29-15)19(32)33/h1-10,16H,(H,30,31)(H,32,33)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444897
(6-((2-chloro-4'-fluoro-5-methoxy-3'-(trifluorometh...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C24H18ClF4N5O5S/c1-30-23(35)34(22-6-4-14(12-31-22)40(36,37)33-21-7-8-39-32-21)19-11-17(25)15(10-20(19)38-2)13-3-5-18(26)16(9-13)24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463850
(CHEMBL4241349)Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F |r| Show InChI InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50008700
(CHEMBL3235969)Show SMILES C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(cc1)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H18F6N2O/c1-12(19(21,22)23)27-18(29)28-11-10-13-4-2-3-5-16(13)17(28)14-6-8-15(9-7-14)20(24,25)26/h2-9,12,17H,10-11H2,1H3,(H,27,29)/t12-,17+/m0/s1 | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometry |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM50201179
(CHEMBL2325007)Show SMILES FC(F)(F)c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1cn[nH]c1 Show InChI InChI=1S/C19H11F3N6O3S2/c20-19(21,22)13-1-3-17(15(6-13)12-8-25-26-9-12)31-16-4-2-14(5-11(16)7-23)33(29,30)28-18-24-10-27-32-18/h1-6,8-10H,(H,25,26)(H,24,27,28) | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as inhibition of sodium current at holding potential of -125 mV measured for 3 to 5 min... |
ACS Med Chem Lett 7: 1062-1067 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00243
BindingDB Entry DOI: 10.7270/Q2VM4F65 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50008709
(CHEMBL3235976)Show SMILES Fc1ccc(NC(=O)N2CCc3cccnc3[C@H]2c2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C22H17F4N3O/c23-17-7-9-18(10-8-17)28-21(30)29-13-11-14-2-1-12-27-19(14)20(29)15-3-5-16(6-4-15)22(24,25)26/h1-10,12,20H,11,13H2,(H,28,30)/t20-/m1/s1 | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin challenge by luminometry |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463876
(CHEMBL4238921)Show SMILES COc1ccc(cn1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H15F6N3O2/c1-32-16-9-6-13(11-29-16)19(31)30-17(12-4-7-14(8-5-12)20(22,23)24)18-15(21(25,26)27)3-2-10-28-18/h2-11,17H,1H3,(H,30,31)/t17-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Mus musculus) | BDBM50463855
(CHEMBL4248077)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50157698
(CHEMBL3787249)Show SMILES Cc1ccnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C19H16ClN5O2/c1-12-8-9-21-18-17(12)19(26)25(11-22-18)10-16-23-15(24-27-16)7-4-13-2-5-14(20)6-3-13/h2-3,5-6,8-9,11H,4,7,10H2,1H3 | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-i... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Mus musculus) | BDBM50463863
(CHEMBL4251467)Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C21H13F6N3O3/c22-20(23,24)13-6-3-11(4-7-13)16(17-14(21(25,26)27)2-1-9-28-17)30-18(31)15-8-5-12(10-29-15)19(32)33/h1-10,16H,(H,30,31)(H,32,33)/t16-/m0/s1 | PDB
Reactome pathway
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM342904
(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)Show SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C26H17F4N3O4S/c1-36-23-14-20(15-3-2-4-17(11-15)26(28,29)30)22(27)13-21(23)25-19-6-5-18(12-16(19)7-9-31-25)38(34,35)33-24-8-10-37-32-24/h2-14H,1H3,(H,32,33) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assay |
J Med Chem 60: 5969-5989 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01851
BindingDB Entry DOI: 10.7270/Q2RJ4MS7 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444870
(6-((2-chloro-5-methoxy-3'-(trifluoromethyl)-4- | U...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(Cl)c(cc1OC)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H19ClF3N5O5S/c1-29-23(34)33(22-7-6-16(13-30-22)39(35,36)32-21-8-9-38-31-21)19-12-18(25)17(11-20(19)37-2)14-4-3-5-15(10-14)24(26,27)28/h3-13H,1-2H3,(H,29,34)(H,31,32) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50008716
(CHEMBL3235983)Show SMILES C[C@H](NC(=O)N1CCc2ccccc2[C@H]1c1ccc(c(F)c1)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H17F7N2O/c1-11(19(22,23)24)28-18(30)29-9-8-12-4-2-3-5-14(12)17(29)13-6-7-15(16(21)10-13)20(25,26)27/h2-7,10-11,17H,8-9H2,1H3,(H,28,30)/t11-,17+/m0/s1 | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin chall... |
J Med Chem 57: 2989-3004 (2014)
Article DOI: 10.1021/jm401955h
BindingDB Entry DOI: 10.7270/Q2NG4S5M |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463859
(CHEMBL4245257)Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-9-7-15(8-10-17)20(21-18(24(28,29)30)4-2-12-32-21)33-22(34)16-6-5-14-3-1-11-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444926
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C25H19F5N6O5S/c1-31-24(37)36(22-7-5-15(13-34-22)42(38,39)35-23-32-8-3-9-33-23)19-12-18(27)16(11-21(19)40-2)14-4-6-17(26)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50157631
(CHEMBL3785736)Show SMILES Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of methylgl... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Mus musculus) | BDBM444926
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ncccn1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C25H19F5N6O5S/c1-31-24(37)36(22-7-5-15(13-34-22)42(38,39)35-23-32-8-3-9-33-23)19-12-18(27)16(11-21(19)40-2)14-4-6-17(26)20(10-14)41-25(28,29)30/h3-13H,1-2H3,(H,31,37)(H,32,33,35) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463858
(CHEMBL4246904)Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H14F7N3O/c25-18-11-14(7-8-16(18)23(26,27)28)20(21-17(24(29,30)31)4-2-10-33-21)34-22(35)15-6-5-13-3-1-9-32-19(13)12-15/h1-12,20H,(H,34,35)/t20-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM444866
(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)Show SMILES CNC(=O)N(c1ccc(cn1)S(=O)(=O)Nc1ccon1)c1cc(F)c(cc1OC)-c1ccc(F)c(OC(F)(F)F)c1 Show InChI InChI=1S/C24H18F5N5O6S/c1-30-23(35)34(22-6-4-14(12-31-22)41(36,37)33-21-7-8-39-32-21)18-11-17(26)15(10-20(18)38-2)13-3-5-16(25)19(9-13)40-24(27,28)29/h3-12H,1-2H3,(H,30,35)(H,32,33) | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128892
BindingDB Entry DOI: 10.7270/Q29027RX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463849
(CHEMBL4250626)Show SMILES OC(=O)c1ccc(cc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F |r| Show InChI InChI=1S/C21H13F5N2O4/c22-14-2-1-9-27-18(14)17(13-7-8-16(15(23)10-13)32-21(24,25)26)28-19(29)11-3-5-12(6-4-11)20(30)31/h1-10,17H,(H,28,29)(H,30,31)/t17-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50157631
(CHEMBL3785736)Show SMILES Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-ind... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463850
(CHEMBL4241349)Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)c1ncccc1F |r| Show InChI InChI=1S/C20H12F5N3O4/c21-12-2-1-7-26-17(12)16(10-4-6-15(13(22)8-10)32-20(23,24)25)28-18(29)14-5-3-11(9-27-14)19(30)31/h1-9,16H,(H,28,29)(H,30,31)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50157631
(CHEMBL3785736)Show SMILES Cn1cnc2ncn(Cc3nc(CCc4ccc(Cl)cc4)no3)c(=O)c12 Show InChI InChI=1S/C17H15ClN6O2/c1-23-9-19-16-15(23)17(25)24(10-20-16)8-14-21-13(22-26-14)7-4-11-2-5-12(18)6-3-11/h2-3,5-6,9-10H,4,7-8H2,1H3 | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-i... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50463862
(CHEMBL4248426)Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc2ncccc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-8-5-14(6-9-17)20(21-18(24(28,29)30)4-2-12-32-21)33-22(34)16-7-10-19-15(13-16)3-1-11-31-19/h1-13,20H,(H,33,34)/t20-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50463855
(CHEMBL4248077)Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi... |
J Med Chem 61: 8186-8201 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50157652
(CHEMBL3785110)Show InChI InChI=1S/C18H14ClN5O2/c19-13-6-3-12(4-7-13)5-8-15-22-16(26-23-15)10-24-11-21-17-14(18(24)25)2-1-9-20-17/h1-4,6-7,9,11H,5,8,10H2 | PDB
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Amgen, Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of AITC-ind... |
J Med Chem 59: 2794-809 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00039
BindingDB Entry DOI: 10.7270/Q2F47R17 |
More data for this
Ligand-Target Pair | |
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