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Compile Data Set for Download or QSAR

Found 45 hits with Last Name = 'mcmillan' and Initial = 'bj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572983
PNG
(CHEMBL4848846)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)c(Cl)c1=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
2.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572968
PNG
(CHEMBL4862851)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
8.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572964
PNG
(CHEMBL4867592)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)N1CCCCCC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.90E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572989
PNG
(CHEMBL4846332)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)cc2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
3.60E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572991
PNG
(CHEMBL4858967)
Show SMILES C[C@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
4.20E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572990
PNG
(CHEMBL4859105)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
4.90E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572988
PNG
(CHEMBL4855695)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(F)cc2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
5.80E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572984
PNG
(CHEMBL4874198)
Show SMILES C[C@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)c(Cl)c1=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
7.80E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Covalent inhibition of human PRMT5 assessed as initial binding constant by LC-MS analysis


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572983
PNG
(CHEMBL4848846)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)c(Cl)c1=O |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572986
PNG
(CHEMBL4878031)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(F)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 370n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572968
PNG
(CHEMBL4862851)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572970
PNG
(CHEMBL4876393)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccncc1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572976
PNG
(CHEMBL4848878)
Show SMILES Cc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc(c1C)S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572964
PNG
(CHEMBL4867592)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)N1CCCCCC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572974
PNG
(CHEMBL4853507)
Show SMILES CCc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572978
PNG
(CHEMBL4877617)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)nc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572969
PNG
(CHEMBL4867285)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1cccnc1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572965
PNG
(CHEMBL4875218)
Show SMILES CN1CCCN(CC1)S(=O)(=O)c1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)ccc1C
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572975
PNG
(CHEMBL4867497)
Show SMILES Cc1cc(C)c(cc1NC(=O)Cn1ncc(Cl)c(Cl)c1=O)S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572990
PNG
(CHEMBL4859105)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Disruption of human N-terminal SmBiT peptide-tagged PRMT5/ N-terminal LgBiT tagged RIOK1 complex expressed in permeabilized HEK293T cells by NanoBiT ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572966
PNG
(CHEMBL4849760)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)ccc1C
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.01E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572964
PNG
(CHEMBL4867592)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)N1CCCCCC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.24E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM67000
PNG
(2-(4,5-dichloro-6-keto-pyridazin-1-yl)-N-(4-methyl...)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C18H20Cl2N4O4S/c1-12-5-6-13(9-15(12)29(27,28)23-7-3-2-4-8-23)22-16(25)11-24-18(26)17(20)14(19)10-21-24/h5-6,9-10H,2-4,7-8,11H2,1H3,(H,22,25)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.27E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572990
PNG
(CHEMBL4859105)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.38E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572967
PNG
(CHEMBL4851976)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)ccc1C
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.41E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572972
PNG
(CHEMBL4863245)
Show SMILES Clc1cnn(CC(=O)Nc2cccc(c2)S(=O)(=O)NCCc2ccccn2)c(=O)c1Cl
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.92E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572973
PNG
(CHEMBL4864955)
Show SMILES COc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.33E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572991
PNG
(CHEMBL4858967)
Show SMILES C[C@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.17E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572988
PNG
(CHEMBL4855695)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(F)cc2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a 3.56E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572977
PNG
(CHEMBL4858632)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)c1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a 3.90E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572984
PNG
(CHEMBL4874198)
Show SMILES C[C@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)c(Cl)c1=O |r|
PDB

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n/an/a 5.54E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572987
PNG
(CHEMBL4858440)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(F)c(C)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a 7.21E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572989
PNG
(CHEMBL4846332)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)cc2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a 7.29E+4n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572971
PNG
(CHEMBL4877019)
Show SMILES CS[C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)n1cnc2c(N)ncnc12 |r|
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50462572
PNG
(CHEMBL4249337)
Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br |r|
Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
PDB

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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM177922
PNG
(US10307413, Compound 337 | US10391089, Compound 16...)
Show SMILES O[C@@H](CNC(=O)c1cc(NC2COC2)ncn1)CN1CCc2ccccc2C1 |r|
Show InChI InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572968
PNG
(CHEMBL4862851)
Show SMILES Cc1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a 1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells measured up to 4 hrs at10 mins time ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572992
PNG
(CHEMBL4873819)
Show SMILES C[C@@H](C(=O)N(C)c1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572985
PNG
(CHEMBL4866410)
Show SMILES CC(C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)c(C)c1=O
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572982
PNG
(CHEMBL4861803)
Show SMILES CN(C(=O)Cn1ncc(Cl)c(Cl)c1=O)c1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572979
PNG
(CHEMBL4849326)
Show SMILES CN1CCCN(CC1)S(=O)(=O)c1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cnc1C
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572980
PNG
(CHEMBL4875323)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)ncc1C
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572981
PNG
(CHEMBL4865606)
Show SMILES CN(C)S(=O)(=O)N1CCCC(C1)NC(=O)Cn1ncc(Cl)c(Cl)c1=O
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572993
PNG
(CHEMBL4850835)
Show SMILES Cc1ccc(NC(=O)Cn2nccc(Cl)c2=O)cc1S(=O)(=O)NCCc1ccccn1
PDB

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n/an/a>2.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50572990
PNG
(CHEMBL4859105)
Show SMILES C[C@@H](C(=O)Nc1ccc(C)c(c1)S(=O)(=O)NCCc1ccccn1)n1ncc(Cl)cc1=O |r|
PDB

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n/an/an/an/a 3.00E+3n/an/an/an/a


TBA

Assay Description
Activity at human wild type PRMT5/HA-tagged WDR77 hetero octameric complex expressed in HEK293 (Expi293) cells assessed as PRMT5 adduct formation inc...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00507
BindingDB Entry DOI: 10.7270/Q26977DH
More data for this
Ligand-Target Pair