BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Methylosome protein 50/Protein arginine N-methyltransferase 5' and Ligand = 'BDBM177922'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...				Citation and Details Article DOI: 10.1021/acsmedchemlett.5b00380 BindingDB Entry DOI: 10.7270/Q2SQ941H
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
University of Jinan Curated by ChEMBL					Assay Description Inhibition of full length recombinant human FLAG-tagged PRMT5/full length recombinant human His6-tagged MEP50 expressed in baculovirus infected Sf9 i...				Bioorg Med Chem Lett 28: 1476-1483 (2018) Article DOI: 10.1016/j.bmcl.2018.03.087 BindingDB Entry DOI: 10.7270/Q2CN76D3
University of Jinan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
University of Jinan Curated by ChEMBL					Assay Description Inhibition of human recombinant PRMT5/MEP50 expressed in 293-F cells using histone 4 peptide as substrate after 90 mins in presence of [3H]SAM by aut...				Bioorg Med Chem Lett 28: 3693-3699 (2018) Article DOI: 10.1016/j.bmcl.2018.10.026 BindingDB Entry DOI: 10.7270/Q2SB490F
University of Jinan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human PRMT5/MEP50 assessed as reduction in methyltransferase activity using histone 4 peptide as substrate in presence of [3H]SAM incub...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01111 BindingDB Entry DOI: 10.7270/Q2765K17
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...				Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 BindingDB Entry DOI: 10.7270/Q2RR22Q1
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
University of Jinan Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...				Bioorg Med Chem Lett 28: 3693-3699 (2018) Article DOI: 10.1016/j.bmcl.2018.10.026 BindingDB Entry DOI: 10.7270/Q2SB490F
University of Jinan Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...				Eur J Med Chem 164: 317-333 (2019) Article DOI: 10.1016/j.ejmech.2018.12.065 BindingDB Entry DOI: 10.7270/Q2RR22Q1
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description General Procedure for PRMT5/MEP50 AlphaLISA Enzyme Inhibitory Assays: Assays were performed in the buffer consisting of 50 mM Tris, pH 8.5, 5 mM MgCl...				Citation and Details BindingDB Entry DOI: 10.7270/Q28K7F1F
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10391089 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B7D
Epizyme, Inc. US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM177922 (US10307413, Compound 337 \| US10391089, Compound 16...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorophore-labeled RIOK1 from human PRMT5/WDR77 hetero octameric complex expressed in Sf9 cells by competition fluorescence polariza...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00507 BindingDB Entry DOI: 10.7270/Q26977DH
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)