Compile Data Set for Download or QSAR

Found 94 hits with Last Name = 'kalyanaraman' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM68853 (1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...) Show SMILES FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI InChI=1S/C17H13F3N2S/c18-17(19,20)14-8-6-13(7-9-14)12-23-16-21-10-11-22(16)15-4-2-1-3-5-15/h1-11H,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572161 (CHEMBL1520238) Show SMILES Brc1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572159 (CHEMBL1489870) Show SMILES Clc1ccc(cc1)-c1nnc(o1)C1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572162 (CHEMBL1352020) Show SMILES CCc1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM56150 ((6E)-4-methyl-6-[5-(2-methylphenyl)-1,2-dihydropyr...) Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1ccccc1C Show InChI InChI=1S/C17H16N2O/c1-11-7-8-17(20)14(9-11)16-10-15(18-19-16)13-6-4-3-5-12(13)2/h3-10,20H,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Competitive inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by Dixon plot analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572160 (CHEMBL1452107) Show SMILES Cc1ccc(CSc2ncn(n2)-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 Q547L mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of wild type human N-terminal His6-tagged 15-LOX-1 expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visib...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 R402L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX12 (Homo sapiens (Human))	BDBM50577453 (CHEMBL4869861) Show SMILES COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3c(ccc4ccccc34)s2)c1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116347 BindingDB Entry DOI: 10.7270/Q28W3J35
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 R404L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 I417A mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 F414I mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 R402L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 E356Q mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 I417A mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50417153 (CHEMBL1270704) Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H18N2O3S/c30-26(22-15-14-19-8-1-2-10-21(19)18-22)31-16-5-6-17-33-27-29-28-25(32-27)24-13-7-11-20-9-3-4-12-23(20)24/h1-4,7-15,18H,16-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 F414W mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 R404L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 Q547L mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of wild type human N-terminal His6-tagged 15-LOX-1 expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visib...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM68853 (1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...) Show SMILES FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI InChI=1S/C17H13F3N2S/c18-17(19,20)14-8-6-13(7-9-14)12-23-16-21-10-11-22(16)15-4-2-1-3-5-15/h1-11H,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX12 (Homo sapiens (Human))	BDBM50447175 (CHEMBL3113165 | US10752581, Compound 35) Show SMILES COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3s2)c1O Show InChI InChI=1S/C21H19N3O4S2/c1-28-18-7-4-5-14(20(18)25)13-22-15-9-11-16(12-10-15)30(26,27)24-21-23-17-6-2-3-8-19(17)29-21/h2-12,22,25H,13H2,1H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116347 BindingDB Entry DOI: 10.7270/Q28W3J35
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 L407A mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572161 (CHEMBL1520238) Show SMILES Brc1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 F414W mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50208823 (6,11-dihydrothiochromeno[4,3-b]indole | CHEMBL1809...) Show SMILES C1Sc2ccccc2-c2[nH]c3ccccc3c12 Show InChI InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572162 (CHEMBL1352020) Show SMILES CCc1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 E356Q mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophot...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572159 (CHEMBL1489870) Show SMILES Clc1ccc(cc1)-c1nnc(o1)C1CCCCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15B (Homo sapiens (Human))	BDBM50572160 (CHEMBL1452107) Show SMILES Cc1ccc(CSc2ncn(n2)-c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM56150 ((6E)-4-methyl-6-[5-(2-methylphenyl)-1,2-dihydropyr...) Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1ccccc1C Show InChI InChI=1S/C17H16N2O/c1-11-7-8-17(20)14(9-11)16-10-15(18-19-16)13-6-4-3-5-12(13)2/h3-10,20H,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM49247 ((6Z)-6-[5-(2-chlorophenyl)-1,2-dihydropyrazol-3-yl...) Show SMILES Oc1ccccc1-c1cc([nH]n1)-c1ccccc1Cl Show InChI InChI=1S/C15H11ClN2O/c16-12-7-3-1-5-10(12)13-9-14(18-17-13)11-6-2-4-8-15(11)19/h1-9,19H,(H,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM79800 (5-(methylamino)-2-(1-naphthalenyl)-4-oxazolecarbon...) Show SMILES CNc1oc(nc1C#N)-c1cccc2ccccc12 Show InChI InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged 15-LOX-1 F414I mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Vi...				Bioorg Med Chem 24: 5380-5387 (2016) Article DOI: 10.1016/j.bmc.2016.08.063 BindingDB Entry DOI: 10.7270/Q28D00SJ
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148015 (CHEMBL1540577) Show SMILES COc1ccc(cc1)-c1cc([nH]n1)-c1cc(OC)ccc1O Show InChI InChI=1S/C17H16N2O3/c1-21-12-5-3-11(4-6-12)15-10-16(19-18-15)14-9-13(22-2)7-8-17(14)20/h3-10,20H,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50187067 (2-(5-(2-chlorophenyl)-1H-pyrazol-3-yl)-4-methoxyph...) Show SMILES COc1ccc(O)c(c1)-c1cc(n[nH]1)-c1ccccc1Cl Show InChI InChI=1S/C16H13ClN2O2/c1-21-10-6-7-16(20)12(8-10)15-9-14(18-19-15)11-4-2-3-5-13(11)17/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148017 (CHEMBL1353771) Show SMILES Oc1ccccc1-c1cc([nH]n1)-c1ccco1 Show InChI InChI=1S/C13H10N2O2/c16-12-5-2-1-4-9(12)10-8-11(15-14-10)13-6-3-7-17-13/h1-8,16H,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM57040 ((6E)-6-[5-(3-bromophenyl)-1,2-dihydropyrazol-3-yli...) Show SMILES COc1ccc(O)c(c1)-c1cc([nH]n1)-c1cccc(Br)c1 Show InChI InChI=1S/C16H13BrN2O2/c1-21-12-5-6-16(20)13(8-12)15-9-14(18-19-15)10-3-2-4-11(17)7-10/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148019 (CHEMBL1604272) Show SMILES Cc1ccccc1-c1cc([nH]n1)-c1ccccc1O Show InChI InChI=1S/C16H14N2O/c1-11-6-2-3-7-12(11)14-10-15(18-17-14)13-8-4-5-9-16(13)19/h2-10,19H,1H3,(H,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148023 (CHEMBL1448722) Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1cccc(Br)c1 Show InChI InChI=1S/C16H13BrN2O/c1-10-5-6-16(20)13(7-10)15-9-14(18-19-15)11-3-2-4-12(17)8-11/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148018 (CHEMBL1372333) Show SMILES COc1ccc(cc1)-c1cc([nH]n1)-c1ccccc1O Show InChI InChI=1S/C16H14N2O2/c1-20-12-8-6-11(7-9-12)14-10-15(18-17-14)13-4-2-3-5-16(13)19/h2-10,19H,1H3,(H,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM78048 ((6E)-6-[5-(3-fluorophenyl)-1,2-dihydropyrazol-3-yl...) Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1cccc(F)c1 Show InChI InChI=1S/C16H13FN2O/c1-10-5-6-16(20)13(7-10)15-9-14(18-19-15)11-3-2-4-12(17)8-11/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM49390 ((6Z)-3-methyl-6-[5-(2-methylphenyl)-1,2-dihydropyr...) Show SMILES Cc1ccc(-c2cc([nH]n2)-c2ccccc2C)c(O)c1 Show InChI InChI=1S/C17H16N2O/c1-11-7-8-14(17(20)9-11)16-10-15(18-19-16)13-6-4-3-5-12(13)2/h3-10,20H,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM114790 ((6Z)-6-[5-(4-fluorophenyl)-1,2-dihydropyrazol-3-yl...) Show SMILES Cc1ccc(-c2cc([nH]n2)-c2ccc(F)cc2)c(O)c1 Show InChI InChI=1S/C16H13FN2O/c1-10-2-7-13(16(20)8-10)15-9-14(18-19-15)11-3-5-12(17)6-4-11/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148014 (CHEMBL1370300) Show SMILES COc1ccc(O)c(c1)-c1cc([nH]n1)-c1ccc(F)cc1 Show InChI InChI=1S/C16H13FN2O2/c1-21-12-6-7-16(20)13(8-12)15-9-14(18-19-15)10-2-4-11(17)5-3-10/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148013 (CHEMBL1520849) Show SMILES Cc1ccc(-c2cc([nH]n2)-c2ccccc2Cl)c(O)c1 Show InChI InChI=1S/C16H13ClN2O/c1-10-6-7-12(16(20)8-10)15-9-14(18-19-15)11-4-2-3-5-13(11)17/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM49265 ((6Z)-6-[5-(3-fluorophenyl)-1,2-dihydropyrazol-3-yl...) Show SMILES Cc1ccc(-c2cc([nH]n2)-c2cccc(F)c2)c(O)c1 Show InChI InChI=1S/C16H13FN2O/c1-10-5-6-13(16(20)7-10)15-9-14(18-19-15)11-3-2-4-12(17)8-11/h2-9,20H,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human))	BDBM50148016 (CHEMBL1718182) Show SMILES Oc1ccccc1-c1cc([nH]n1)-c1ccccc1 Show InChI InChI=1S/C15H12N2O/c18-15-9-5-4-8-12(15)14-10-13(16-17-14)11-6-2-1-3-7-11/h1-10,18H,(H,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis				Bioorg Med Chem 24: 1183-90 (2016) Article DOI: 10.1016/j.bmc.2016.01.042 BindingDB Entry DOI: 10.7270/Q2QJ7K44
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX8 (Mus musculus)	BDBM50572161 (CHEMBL1520238) Show SMILES Brc1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair
Polyunsaturated fatty acid lipoxygenase ALOX8 (Mus musculus)	BDBM68853 (1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...) Show SMILES FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 Show InChI InChI=1S/C17H13F3N2S/c18-17(19,20)14-8-6-13(7-9-14)12-23-16-21-10-11-22(16)15-4-2-1-3-5-15/h1-11H,12H2	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis				Citation and Details Article DOI: 10.1016/j.bmc.2021.116349 BindingDB Entry DOI: 10.7270/Q2HX1HF0
					More data for this Ligand-Target Pair

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